Long-term results of celiac disease patients who underwent liver transplantation

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dc.contributor.authorAltun, Caner
dc.contributor.authorSaglam, Osman
dc.contributor.authorKeser, Muhammed Furkan
dc.contributor.authorAtaman, Engin
dc.contributor.authorEfe, Cumali Savas
dc.contributor.authorBurkek, Hilal
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2026-04-04T13:33:01Z
dc.date.available2026-04-04T13:33:01Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground and Aim: Although there are a few studies reporting transplantation for celiac disease (CD), there are no studies reporting long-term outcomes after transplantation in CD patients. Therefore, we aimed to report the long-term outcomes of patients who underwent liver transplantation (LT) for CD in our high-volume liver transplantation center. Materials and Methods: Our study was a single-center, retrospective study and included 28 CD patients who underwent LT at Inonu University. CD diagnosis was made based on anti-tissue transglutaminase or anti-endomysium antibody positivity and/or duodenal biopsy results. Results: The 1-, 3-, 5-, and 10-year survival rates after transplantation were 92.9%, 92.9%, 84.4%, and 75%, respectively. The most striking finding in the study was the high frequency of biliary complications. Another important finding was the significant difference in body mass index (BMI) between pre-transplant and post-transplant (p<0.001). The incidence of rejection and recurrence was 39.1% and 25%, respectively. The number of patients with high anti-tissue transglutaminase (anti-TTG) levels after transplantation decreased significantly (p<0.001). Conclusion: Our study suggests that the frequency of post-transplant biliary complications is very high in CD patients and that LT had positive effects on BMI and anti-tissue transglutaminase levels.
dc.identifier.doi10.14744/hf.2025.46960
dc.identifier.endpage159
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue4
dc.identifier.orcid0000-0002-4524-9761
dc.identifier.pmid41122155
dc.identifier.scopus2-s2.0-105019762811
dc.identifier.scopusqualityQ3
dc.identifier.startpage151
dc.identifier.urihttps://doi.org/10.14744/hf.2025.46960
dc.identifier.urihttps://hdl.handle.net/11616/108877
dc.identifier.volume6
dc.identifier.wosWOS:001593114500003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofHepatology Forum
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCeliac disease
dc.subjectliver
dc.subjecttransplantation
dc.titleLong-term results of celiac disease patients who underwent liver transplantation
dc.typeArticle

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