Synthesis of some benzimidazole derivatives and their antibacterial and antifungal activities

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorKüçükbay, H
dc.contributor.authorDurmaz, R
dc.contributor.authorGüven, M
dc.contributor.authorGünal, S
dc.date.accessioned2024-08-04T20:11:46Z
dc.date.available2024-08-04T20:11:46Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA number of new benzimidazole derivatives were synthesized by the reaction of benzimidazole with appropriate alkyl halides. The compounds synthesized were intentified by H-1-NMR, Fourier Transformation Infrared (FT-IR) and micro analysis. All new and related compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and the yeasts Candida albicans and Candida tropicalis. Eleven of the compounds were found effective to inhibit the growth of Gram-positive bacteria (E. faecalis and S. aureus) at MIC values between 12.5-400 mug/ml. None of the compounds exhibited antimicrobial activity against Gram-negative bacteria (E. coli and P. aeruginosa) at the concentrations studied (6.25-800 mug/ml). All compounds (except compound 3) were significantly effective against C. tropicalis with MIC values of 6.25-400 mug/ml. Eight of the tested compounds showed an antifungal activity against C. albicans with a range of the MICs between 50 and 400 mug/ml.en_US
dc.identifier.endpage424en_US
dc.identifier.issn0004-4172
dc.identifier.issue5en_US
dc.identifier.pmid11413744en_US
dc.identifier.scopus2-s2.0-0008625468en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage420en_US
dc.identifier.urihttps://hdl.handle.net/11616/92988
dc.identifier.volume51en_US
dc.identifier.wosWOS:000168941700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEcv-Editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.ispartofArzneimittel-Forschung-Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbenzimidazole derivativesen_US
dc.subjectantibacterial activitesen_US
dc.subjectantifungal activitiesen_US
dc.subjectin vitro studiesen_US
dc.subjectsynthesisen_US
dc.titleSynthesis of some benzimidazole derivatives and their antibacterial and antifungal activitiesen_US
dc.typeArticleen_US

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