The role of ghrelin in weight gain and growth in epileptic children using valproate

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridYücel, Gül/0000-0001-5753-9048
dc.authoridAkinci, Aysehan/0000-0001-7267-9444
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidYücel, Gül/JEF-1599-2023
dc.authorwosidAkinci, Aysehan/AAC-6847-2021
dc.contributor.authorGungor, Serdal
dc.contributor.authorYucel, Gul
dc.contributor.authorAkinci, Aysehan
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorOzerol, Ibrahim Halil
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:30:38Z
dc.date.available2024-08-04T20:30:38Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractGhrelin is a major hormone, regulating the energy balance of the body. weight gain is a significant side effect of valproic acid, which has not been clearly identified pathogenetically. The aim of this study was to investigate the effect of valproic acid on ghrelin and its potential effects on weight gain and growth. Each patient and control group consisted of 35 children aged 3 to 15 years. Fasting serum glucose, insulin, C-peptide, leptin, ghrelin, insulin-like growth factor-1, and insulin-like growth factor binding protein-3 levels were measured in patients treated with valproic acid before and at month 6 of treatment. A significant increase in body weight body mass index, height, and height standard deviation scores was observed in all patients after 6 months of treatment. Significant increases in growth velocity and weight gain were observed in the patient group compared with controls at 6 months of therapy. A significant increase in serum ghrelin levels (P <.01) was detected at the same time in the study group. A negative correlation of ghrelin with insulin-like growth factor-1 and insulin-like growth factor binding protein-3 was detected. Serum ghrelin levels were significantly increased (P <.05), and insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels were significantly decreased (P <.01 and P <.05, respectively) in the prepubertal group at 6 months of treatment, but no significant change was observed in the pubertal group. Consequently, ghrelin levels significantly increase in the prepubertal children treated with valproic acid. The weight gain in using valproic acid may be associated with the increase in ghrelin level in the early treatment period.en_US
dc.identifier.doi10.1177/0883073807307096
dc.identifier.endpage1388en_US
dc.identifier.issn0883-0738
dc.identifier.issn1708-8283
dc.identifier.issue12en_US
dc.identifier.pmid18174556en_US
dc.identifier.scopus2-s2.0-36749087648en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1384en_US
dc.identifier.urihttps://doi.org/10.1177/0883073807307096
dc.identifier.urihttps://hdl.handle.net/11616/94410
dc.identifier.volume22en_US
dc.identifier.wosWOS:000251591400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal of Child Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectghrelinen_US
dc.subjectvalproateen_US
dc.subjectbody weighten_US
dc.titleThe role of ghrelin in weight gain and growth in epileptic children using valproateen_US
dc.typeArticleen_US

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