The Relationship of Serum Vitamin B12 and Ferritin Levels with Disease Severity and Neuropathic Pain in Fibromyalgia Syndrome

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dc.contributor.authorBingol, Meral Kirmizi
dc.contributor.authorAkturk, Semra
dc.contributor.authorBuyukavci, Raikan
dc.contributor.authorZontul, Sezgin
dc.date.accessioned2026-04-04T13:31:20Z
dc.date.available2026-04-04T13:31:20Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: To investigate the relationship of serum vitamin B12 (vB12) and ferritin levels with disease severity and neuropathic pain in fibromyalgia syndrome (FMS). Study Design: Observational study. Place and Duration of the Study: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Inonu University, Malatya, Turkiye, from October to December 2023. Methodology: A total of 110 patients, aged between 18 and 65 years, diagnosed with FMS according to the 2016 ACR diagnostic criteria, were included in this study. The participants were evaluated using the Fibromyalgia Impact Questionnaire (FIQ) to measure symptoms impacting daily activities such as pain, sleep disturbances, and fatigue. The Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) is a clinical scale used to investigate the neuropathic component of pain. The serum levels of vB12 and ferritin were compared between the patients with and without neuropathic pain symptoms and the impact of these parameters on disease severity and activities of daily life was analysed. Results: Among the participants, 105 were females and 5 were males. Sixty-nine patients reported neuropathic pain, while 41 did not. Patients with neuropathic pain had significantly higher VAS and FIQ scores and significantly lower vB12 and ferritin levels (p <0.05). A significant inverse relationship was found between FIQ scores and both vB12 levels (p = 0.047, r =-0.190) and ferritin levels (p = 0.007, r =-0.256). Conclusion: In this study, fibromyalgia patients with neuropathic pain had higher pain and disease activity scores, and low serum vB12 and ferritin levels were found to be associated with disease severity and neuropathic pain.
dc.identifier.doi10.29271/jcpsp.2025.02.209
dc.identifier.endpage212
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue2
dc.identifier.orcid0000-0001-5730-2286
dc.identifier.orcid0000-0002-2234-7158
dc.identifier.pmid39936200
dc.identifier.scopus2-s2.0-85218484583
dc.identifier.scopusqualityQ2
dc.identifier.startpage209
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2025.02.209
dc.identifier.urihttps://hdl.handle.net/11616/108744
dc.identifier.volume35
dc.identifier.wosWOS:001440050500014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherColl Physicians & Surgeons Pakistan
dc.relation.ispartofJcpsp-Journal of the College of Physicians and Surgeons Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectFibromyalgia syndrome
dc.subjectNeuropathic pain
dc.subjectVitamin B12
dc.subjectFerritin
dc.subjectPain
dc.titleThe Relationship of Serum Vitamin B12 and Ferritin Levels with Disease Severity and Neuropathic Pain in Fibromyalgia Syndrome
dc.typeArticle

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