Effect of a honey and arginine-glutamine-hydroxymethylbutyrate mixture on the healing of colon anastomosis in rats immunosuppressed with tacrolimus

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.authorwosidDoğan, Zümrüt/GQP-2535-2022
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.contributor.authorAkbulut, S.
dc.contributor.authorDogan, Z.
dc.contributor.authorBaskiran, A.
dc.contributor.authorElbe, H.
dc.contributor.authorTurkoz, Y.
dc.date.accessioned2024-08-04T20:45:53Z
dc.date.available2024-08-04T20:45:53Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe compared the effect of honey and a mixture of arginine-glutamine-hydroxymethylbutyrate (AGHMB) on healing of a descending colon anastomosis in rats that were immunosuppressed with tacrolimus (Tac). Sprague-Dawley rats were divided into four groups: untreated control, Tac, Tac + honey and Tac + AGHMB. Colon resection and anastomosis were performed on day 14 and re-laparotomy was performed on the day 21 of the study. Anastomotic bursting pressure, macroscopic adhesion score, weekly body weight changes, histopathological features and immunohistochemical staining of TGF-beta 1 were determined for all groups. We found no significant difference in anastomotic bursting pressure among the experimental groups. We found significant weekly increases in body weight for the Tac + honey group. We found no significant difference in the weekly body weight measurements for the Tac + AGHMB group. We found significant increases in TGF-beta 1 expression in the Tac + honey group compared to the control and Tac groups. No significant differences in inflammatory cell infiltration, fibroblast proliferation or collagen deposition were found between the Tac + honey and Tac + AGHMB groups; however, a significant difference in neovascularization between these groups was found. Neovascularization in the Tac + honey group was significantly greater than for the Tac + AGHMB group. We found that both honey and the AGHMB mixture were beneficial for anastomotic wound healing in rats that were immunosuppressed using Tac.en_US
dc.identifier.doi10.1080/10520295.2019.1601257
dc.identifier.endpage521en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue7en_US
dc.identifier.pmid30983411en_US
dc.identifier.scopus2-s2.0-85064511913en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage514en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1601257
dc.identifier.urihttps://hdl.handle.net/11616/98765
dc.identifier.volume94en_US
dc.identifier.wosWOS:000466687000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnastomosisen_US
dc.subjectarginineen_US
dc.subjectbursting pressureen_US
dc.subjectcolonen_US
dc.subjectglutamineen_US
dc.subjecthoneyen_US
dc.subjecthydroxymethylbutyrateen_US
dc.subjecttacrolimusen_US
dc.titleEffect of a honey and arginine-glutamine-hydroxymethylbutyrate mixture on the healing of colon anastomosis in rats immunosuppressed with tacrolimusen_US
dc.typeArticleen_US

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