Anxiety and Salivary Cortisol Levels in Children Undergoing Esophago-Gastro-Duodenoscopy Under Sedation

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dc.authoridBayrak, Nevzat Aykut/0000-0002-5553-6123
dc.authoridKara, Duygu/0000-0003-3325-2565;
dc.authorwosidBayrak, Nevzat Aykut/J-6380-2013
dc.authorwosidKara, Duygu/HKE-3410-2023
dc.authorwosidYILDIZ, SEDAT/AAB-6354-2021
dc.contributor.authorKara, Duygu
dc.contributor.authorBayrak, Nevzat Aykut
dc.contributor.authorVolkan, Burcu
dc.contributor.authorUcar, Cihat
dc.contributor.authorCevizci, Mehmet Nuri
dc.contributor.authorYildiz, Sedat
dc.date.accessioned2024-08-04T20:45:37Z
dc.date.available2024-08-04T20:45:37Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Esophagogastroduodenoscopy (EGD) can cause fear and anxiety in children. Cortisol, which is the most important glucocorticoid hormone in humans, can increase under physiological stress. The purpose of this study was to measure the salivary cortisol level (SCL) and anxiety level in patients undergoing EGD and evaluate their effects on the procedure. Methods: Children undergoing EGD under sedoanalgesia with propofol for various reasons were included. Their basal SCLs were compared with those of healthy age- and sex-matched controls. Moreover, SCL of the patient group at 30 minutes before EGD and 2 hours after the procedure were measured. Their anxiety scores were calculated using the modified Yale Preoperative Anxiety Scale before EGD. Duration of endoscopy, sedation, and recovery and total propofol doses were recorded. Results: Demographic properties of the patient group (n = 119; 10.9 +/- 3.2 years; 43.7% boys) and control group (n = 85; 11.8 +/- 2.8 years; 45.1% boys) were not significantly different. Basal SCLs of both groups were similar (16.9 +/- 0.7 vs 19.7 +/- 1.8 ng/mL, P = 0.16). SCL before EGD in the patient group was significantly higher than basal and post-EGD values (P < 0.001 for each). Pre-EGD SCL was positively correlated with anxiety level, propofol dose, and duration of sedation, procedure, and recovery. Anxiety levels of patients were positively correlated with propofol dose and duration of sedation and recovery, and negatively correlated with age. Conclusions: Childhood EGD is a significant stress factor, which was reflected by the pre-procedural SCL in this study. Increased anxiety resulted in increased propofol doses and sedoanalgesia-related procedural durations, which may cause potential complications.en_US
dc.identifier.doi10.1097/MPG.0000000000002142
dc.identifier.endpage6en_US
dc.identifier.issn0277-2116
dc.identifier.issn1536-4801
dc.identifier.issue1en_US
dc.identifier.pmid30169453en_US
dc.identifier.scopus2-s2.0-85059228927en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3en_US
dc.identifier.urihttps://doi.org/10.1097/MPG.0000000000002142
dc.identifier.urihttps://hdl.handle.net/11616/98589
dc.identifier.volume68en_US
dc.identifier.wosWOS:000460950300003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanxietyen_US
dc.subjectpropofolen_US
dc.subjectsalivary cortisolen_US
dc.subjectsedoanalgesiaen_US
dc.titleAnxiety and Salivary Cortisol Levels in Children Undergoing Esophago-Gastro-Duodenoscopy Under Sedationen_US
dc.typeArticleen_US

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