The effectiveness of platelet-rich plasma in an anosmia-induced mice model

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridaraz server, ela/0000-0002-8462-3605
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosiddastan, sevgi durna/AAO-8476-2021
dc.contributor.authorYasak, Ahmet Gorkem
dc.contributor.authorYigit, Ozgur
dc.contributor.authorServer, Ela Araz
dc.contributor.authorDastan, Sevgi Durna
dc.contributor.authorGul, Mehmet
dc.date.accessioned2024-08-04T20:44:16Z
dc.date.available2024-08-04T20:44:16Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectiveIn this study, we aimed to functionally and morphologically demonstrate the effectiveness of platelet-rich plasma (PRP) on anosmia in a mouse model of anosmia. Study DesignAnimal study. MethodsA total of 16 male mice were included. When selecting the mice, the food-finding test (FFT) was used to make sure that the animals could smell, and anosmia was induced by administration of intraperitoneal 3-methylindole. The mice were randomly divided into two groups of eight (groups A and B). After 1 week, topical PRP was administered to the mice in group A and topical saline was administered to the mice in group B. The FFT was again administered at 7, 14, and 21 days. The mice were sacrificed on day 21, the olfactory neuroepithelium was histopathologically examined, and the epithelial damage scores and epithelial thickness were measured. ResultsAfter topical administration of PRP and saline, the difference in the average FFT values of the groups was statistically significant at 7, 14, and 21 days (P < 0,005). During the histopathological examination, the epithelial damage score was statistically significantly lower in the PRP group (P=0.001) than in the saline group, and epithelial thickness was statistically significantly greater in the PRP group compared to the saline group (P=0.003). ConclusionWe showed that PRP administration has a curative effect on olfactory functions in an anosmia-induced mice model. However, there is a need for further research before PRP can be considered for use in patients with anosmia in clinical practice. Level of EvidenceNA. Laryngoscope, 128:E157-E162, 2018en_US
dc.identifier.doi10.1002/lary.27029
dc.identifier.endpageE162en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue5en_US
dc.identifier.pmid29243256en_US
dc.identifier.scopus2-s2.0-85041226178en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE157en_US
dc.identifier.urihttps://doi.org/10.1002/lary.27029
dc.identifier.urihttps://hdl.handle.net/11616/98135
dc.identifier.volume128en_US
dc.identifier.wosWOS:000430472200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofLaryngoscopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSmellen_US
dc.subjectanosmiaen_US
dc.subjecthyposmiaen_US
dc.subject3-methylindoleen_US
dc.subjectplatelet-rich plasmaen_US
dc.titleThe effectiveness of platelet-rich plasma in an anosmia-induced mice modelen_US
dc.typeArticleen_US

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