Metabolic role of hepassocin in polycystic ovary syndrome

Basit Öğe Kaydı
dc.authoridtaşkaldıran, ışılay/0000-0002-1390-7571
dc.authoridCOSKUN, Ebru INCI/0000-0003-4402-3725
dc.authorwosidtaşkaldıran, ışılay/HPD-7908-2023
dc.authorwosidCOSKUN, Ebru INCI/ABI-8238-2020
dc.contributor.authorCoskun, E. inci
dc.contributor.authorOmma, T.
dc.contributor.authorTaskaldiran, I.
dc.contributor.authorFirat, S. N.
dc.contributor.authorCulha, C.
dc.date.accessioned2024-08-04T20:54:29Z
dc.date.available2024-08-04T20:54:29Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Polycystic ovary syndrome (PCOS) is a female endocrinopathy characterized by hyperandrogenemia, insulin resistance, glucose intolerance, dyslipidemia, non-alcoholic fatty liver disease (NAFLD), and obesity. Hepassocin (HPS) is a hepatokine involved in energy and lipid metabolism. We aimed to investigate the role of HPS in metabolic dysfunction and its relationship with fatty liver in patients with PCOS. PATIENTS AND METHODS: A total of 45 newly diagnosed PCOS patients and 42 healthy women of similar age were included in the study. Routine anthropometric, biochemical, and hormonal information were recorded. Serum HPS and high-sensitivity C-reactive protein (hsCRP) were measured, and NAFLD fibrosis score (NFS) and Fibrosis-4 (FIB-4) were calculated and correlated. RESULTS: HPS and hsCRP values of the PCOS group were found to be significantly higher than controls (p=0.005, p<0.001, respectively). A positive correlation was found between both HPS and hsCRP and luteinizing hormone (LH) (p<0.001). No correlation was observed between HPS and NFS and FIB-4, however, only a weak negative correlation was observed between hsCRP and FIB-4. A negative correlation was found between HPS and BMI, waist circumference, fat ratio, and HbA1c (p<0.05). In multi-variate regression analysis for HPS, R-squared is 0.898, and hsCRP, neck circumference, fat amount, and LH are significant factors. CONCLUSIONS: NAFLD is an important dysmetabolic component of PCOS. Serum HPS is elevated in PCOS patients. We found a positive correlation between hsCRP and LH and a negative correlation between obesity indices, although we did not find an association between NFS and FIB-4, and HPS. In the future, large-scale molecular studies of HPS may be beneficial.en_US
dc.identifier.endpage5183en_US
dc.identifier.issn1128-3602
dc.identifier.issue11en_US
dc.identifier.pmid37318492en_US
dc.identifier.scopus2-s2.0-85163902608en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5175en_US
dc.identifier.urihttps://hdl.handle.net/11616/101445
dc.identifier.volume27en_US
dc.identifier.wosWOS:001020918300008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepassocinen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectHyperan-drogenemiaen_US
dc.subjectNon-alcoholic fatty liver diseaseen_US
dc.subjectInsulin resistanceen_US
dc.titleMetabolic role of hepassocin in polycystic ovary syndromeen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu