Synthesis, characterization and bioactivities of dative donor ligand N-heterocyclic carbene (NHC) precursors and their Ag(I)NHC coordination compounds

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dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridsağlamtaş, rüya/0000-0002-4400-2302
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidsağlamtaş, rüya/ABC-8186-2021
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.contributor.authorKazanci, Ali
dc.contributor.authorGok, Yetkin
dc.contributor.authorKaya, Ruya
dc.contributor.authorAktas, Aydin
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:49:04Z
dc.date.available2024-08-04T20:49:04Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study contains the synthesis of N-phthalimidomethyl-substituted NHC precursors and their Ag(I) NHC coordination compounds. The NHC precursors were synthesized from the 1-(N-phthalimidomethyl)benzimidazole and alkyl/aryl halide. The Ag(I)NHC coordination compounds were synthesized from the N-phthalimidomethyl substituted benzimidazolium salts and silver oxide via the in-situ deprotonation method. The formation of all compounds was proved fully by H-1 NMR, C-13 NMR, FTIR and elemental analysis techniques. Also, these novel N-phthalimidomethyl substituted NHC precursors and Ag(I) NHC coordination compounds were found as effective inhibitors for acetylcholinesterase (AChE), human carbonic anhydrase I isoenzyme (hCA I), human carbonic anhydrase II isoenzyme (hCA II), and butyrylcholinesterase (BChE) with inhibition constants (K(i)s) in the range of 1.00 +/- 0.14-2.31 +/- 0.58 mu M for hCA I, 1.30 +/- 0.21-2.85 +/- 0.56 mu M for hCA II, 0.35 +/- 0.06-2.58 +/- 0.70 mu M for AChE, and 0.42 +/- 0.01- 1.27 +/- 0.16 mu M for BChE, respectively. (C) 2020 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University Research Fund [IUBAP-2016/124]; Inonu University Faculty of Science Department of Chemistryen_US
dc.description.sponsorshipThis study was financially supported by Inonu University Research Fund (Project Code: IUBAP-2016/124). The authors thank the Inonu University Faculty of Science Department of Chemistry for the characterization of compounds.en_US
dc.identifier.doi10.1016/j.poly.2020.114866
dc.identifier.issn0277-5387
dc.identifier.issn1873-3719
dc.identifier.scopus2-s2.0-85095707422en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2020.114866
dc.identifier.urihttps://hdl.handle.net/11616/99616
dc.identifier.volume193en_US
dc.identifier.wosWOS:000598080700006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDative donor liganden_US
dc.subjectEnzyme inhibitionen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectN-phthalimidomethylen_US
dc.subjectSilver(I)NHC complexen_US
dc.titleSynthesis, characterization and bioactivities of dative donor ligand N-heterocyclic carbene (NHC) precursors and their Ag(I)NHC coordination compoundsen_US
dc.typeArticleen_US

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