Serum nitric oxide, catalase, superoxide dismutase, and malondialdehyde status in patients with ankylosing spondylitis

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dc.authoridOzgocmen, Salih/0000-0002-4860-452X
dc.authoridOzgocmen, Salih/0000-0002-4860-452X
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidOzgocmen, Salih/K-4680-2019
dc.authorwosidOzgocmen, Salih/K-9588-2015
dc.contributor.authorOzgocmen, S
dc.contributor.authorSogut, S
dc.contributor.authorArdicoglu, O
dc.contributor.authorFadillioglu, E
dc.contributor.authorPekkutucu, I
dc.contributor.authorAkyol, O
dc.date.accessioned2024-08-04T20:13:48Z
dc.date.available2024-08-04T20:13:48Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, serum antioxidant and oxygen derived free radical status of patients with ankylosing spondylitis (AS) was investigated and compared with that of age- and sex-matched healthy controls. The relationship of these parameters to disease activity indices was also examined. Thirty patients with AS not currently under disease-modifying antirheumatic drug (DMARD) treatment (e.g., sulfasalazine or methotrexate) (15 active and 15 inactive) and 16 age- and sex-matched healthy controls were included in the study. Catalase (EC 1.11.1.6), total (Cu-Zn and Mn) superoxide dismutase (SOD) (EC 1.15.1.1) activities, and malondialdehyde (MDA), nitrite (NO2-), and nitrate (NO3-) levels as indices of nitric oxide (NO) production were evaluated using appropriate methods. There was no statistically significant difference found in SOD activity or NO and MDA levels between active and inactive patients. Inactive patients showed no significant difference in all the measured oxidant/antioxidant parameters when compared to healthy controls. Active patients had significantly higher levels of MDA and catalase enzyme activity (P=0.002 and P=0.007, respectively). There was no significant correlation between oxidant/antioxidant parameters and disease activity, C-reactive protein, erythrocyte sedimentation rate, or Bath Ankylosing Spondylitis Disease Activity Index (CRP, ESR, or BASDAI) in either group, except catalase enzyme activity, which had a significant correlation with CRP and ESR levels in active patients (r=0.69 and P=0.004, r=0.52 and P=0.04, respectively). Our results indicate that oxidative stress and lipid peroxidation are accelerated in untreated patients with active AS. Serum catalase activity may be closely related to disease activity. In this regard, we underscore the likely benefit of some therapeutic interventions including high-potential antioxidants that will potentiate the antioxidant defense mechanism and reduce peroxidation in the management of AS.en_US
dc.identifier.doi10.1007/s00296-003-0335-y
dc.identifier.endpage83en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue2en_US
dc.identifier.pmid12811507en_US
dc.identifier.scopus2-s2.0-1642306153en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-003-0335-y
dc.identifier.urihttps://hdl.handle.net/11616/93864
dc.identifier.volume24en_US
dc.identifier.wosWOS:000220026800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectankylosing spondylitisen_US
dc.subjectcatalaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectxanthine oxidaseen_US
dc.titleSerum nitric oxide, catalase, superoxide dismutase, and malondialdehyde status in patients with ankylosing spondylitisen_US
dc.typeArticleen_US

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