Role of oxidative stress in preeclampsia and intrauterine growth restriction

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dc.authoridKaraer, Abdullah/0000-0002-2010-6211;
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidYUKSEL, SERDAR/C-3225-2018
dc.contributor.authorMert, Ismail
dc.contributor.authorOruc, Ayla Sargin
dc.contributor.authorYuksel, Serdar
dc.contributor.authorCakar, Esra Sukran
dc.contributor.authorBuyukkagnici, Umran
dc.contributor.authorKaraer, Abdullah
dc.contributor.authorDanisman, Nuri
dc.date.accessioned2024-08-04T20:35:52Z
dc.date.available2024-08-04T20:35:52Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of the present study was to evaluate the role of oxidative stress and DNA damage in preeclampsia and intrauterine growth restriction (IUGR). Material and Methods: Twenty-four patients with preeclampsia, 20 patients with IUGR fetus and 37 healthy pregnant women were enrolled in the study. The total oxidant status (TOS) and antioxidant status (TAS) of plasma were measured using a novel automated colorimetric measurement method. Sister chromatid exchange (SCE) and micronuclei analysis were performed on peripheral blood lymphocytes of cases and controls. Results: Women whose pregnancies were complicated with preeclampsia and IUGR had elevated levels of TOS and TAS when compared with healthy pregnant women (median TOS values: 9.73, 10.6 and 8.06, P = 0.001; median TAS values: 1 77, 1.54 and 1.44, P < 0.001, respectively). The frequencies of SCE were only found to be increased in women with IUGR fetus compared with healthy pregnant women (8.81 vs 7.5, respectively, P = 0.02). Multivariable linear regression analysis for both TOS and TAS showed a significant relation between these variables and uric acid. Conclusion: Increased oxidative stress and antioxidative defense mechanisms may contribute to disease processes both in preeclampsia and IUGR.en_US
dc.identifier.doi10.1111/j.1447-0756.2011.01771.x
dc.identifier.endpage664en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue4en_US
dc.identifier.pmid22380678en_US
dc.identifier.scopus2-s2.0-84860859602en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage658en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2011.01771.x
dc.identifier.urihttps://hdl.handle.net/11616/95648
dc.identifier.volume38en_US
dc.identifier.wosWOS:000301926100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintrauterine growth restrictionen_US
dc.subjectoxidative stressen_US
dc.subjectpreeclampsiaen_US
dc.subjectsister chromatid exchangeen_US
dc.titleRole of oxidative stress in preeclampsia and intrauterine growth restrictionen_US
dc.typeArticleen_US

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