Systemic Prolidase Activity and Oxidative Stress in Keratoconus

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dc.authoridEvliyaoglu, Osman/0000-0002-5780-9068
dc.authoridKilic, Rasit/0000-0001-6671-9067
dc.authorwosidKılıç, Raşit/AAP-6844-2021
dc.authorwosidSancaktar, Erol/U-3190-2017
dc.authorwosidEVLİYAOĞLU, OSMAN/AAJ-1225-2020
dc.authorwosidEvliyaoglu, Osman/AAR-1055-2021
dc.contributor.authorKilic, Rasit
dc.contributor.authorCumurcu, Tongabay
dc.contributor.authorSancaktar, Enver
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorSezer, Hafize
dc.date.accessioned2024-08-04T20:41:26Z
dc.date.available2024-08-04T20:41:26Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Our aim was to evaluate the serum prolidase activity, total antioxidant capacity (TAC) and total oxidant status (TOS) in patients with keratoconus.Material and method: A total 69 keratoconus patients and 72 control subjects with similar age and gender were evaluated within the scope of this study. The keratoconus group was divided into four stages with the modified Krumeich classification. Serum prolidase activity, TAC and TOS were measured and compared between the patient and control groups.Results: The median serum prolidase enzyme activity value was 528.3 (684.1-416.7) U/L in the keratoconus group and 606.2 (812.9-482.3) U/L in the control group. The difference between the groups was statistically significant (p=0.027). The median TAC value was 1.24 (1.37-1.05) mmol/L in the keratoconus group and 1.29 (1.38-1.18) mmol/L in the control group. The median TOS value was 2 (4-1)mol/L in the keratoconus group and 3 (4-2)mol/L in the control group. There was no statistically significant difference between the two groups in terms of TAC or TOS (p=0.113 and p=0.366, respectively). There was a positive correlation between TAC and TOS in keratoconus group but not in the control group (r=0.670, p=0.001 and r=0.141, p=0.241, respectively). No significant relationship was seen between the keratoconus group stages and serum prolidase activity, TAS or TOS (p=0.894, p=0.155 and p=0.381, respectively).Conclusion: In conclusion, a significant relationship was found between decreased serum prolidase activity and keratoconus but there was no significant relationship between keratoconus and serum TAC or TOS.en_US
dc.identifier.doi10.3109/02713683.2015.1004717
dc.identifier.endpage33en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue1en_US
dc.identifier.pmid25658899en_US
dc.identifier.scopus2-s2.0-84953352336en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2015.1004717
dc.identifier.urihttps://hdl.handle.net/11616/97103
dc.identifier.volume41en_US
dc.identifier.wosWOS:000367530500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKeratoconusen_US
dc.subjectoxidative stressen_US
dc.subjectprolidase activityen_US
dc.subjecttotal antioxidant capacityen_US
dc.subjecttotal oxidant statusen_US
dc.titleSystemic Prolidase Activity and Oxidative Stress in Keratoconusen_US
dc.typeArticleen_US

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