Proteomic Analysis of Liver Preservation Solutions Prior to Liver Transplantation

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dc.authoridOztug, Merve/0000-0002-6287-2774
dc.authoridYAZICI, Cevat/0000-0003-0625-9542
dc.authoridCoskun, Abdurrahman/0000-0002-1273-0604
dc.authoridYAZICI, Cevat/0000-0003-0625-9542
dc.authoridAkgoz, Muslum/0000-0001-5065-8087
dc.authoridKaya, Ekrem/0000-0002-9562-4195
dc.authoridyurtsever, Ilknur/0000-0001-7944-5077
dc.authorwosidOztug, Merve/ABC-4768-2021
dc.authorwosidyurtsever, ilknur/G-2560-2019
dc.authorwosidOztug, Merve/AAH-6132-2021
dc.authorwosidYAZICI, Cevat/A-1313-2012
dc.authorwosidCoskun, Abdurrahman/C-3906-2015
dc.authorwosidYAZICI, Cevat/AAE-2558-2019
dc.authorwosidAkgoz, Muslum/AAG-4598-2019
dc.contributor.authorCoskun, Abdurrahman
dc.contributor.authorBaykal, Ahmet Tarik
dc.contributor.authorOztug, Merve
dc.contributor.authorKazan, Dilek
dc.contributor.authorKaya, Ekrem
dc.contributor.authorEmiroglu, Remzi
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:45:54Z
dc.date.available2024-08-04T20:45:54Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Transplantation is the preferred treatment for patients with end-stage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although various protective solutions are used (in combination with hypothermia), the functional preservation time for liver is still limited to hours. We analyzed the preservation medium to detect the proteins released from the liver during storage period. Material/Methods: Samples were collected from the pre-transplant preservation mediums of 23 liver donors. For all donors, the cases involved Donation after Brain Death (DBD). 2D-PAGE and LCMSMS methodologies were used to detect the proteins and peptides from the preservation mediums. Results: A total of 198 proteins originating from the liver were detected. Conclusion: The data provide valuable insights into biomarkers that may be used to evaluate organ injury, functional status, and suitability for transplantation. Additionally, the findings could be valuable for the development of new strategies for effective preservation of solid organs prior to transplantation.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [110S103]en_US
dc.description.sponsorshipThis study was financed by The Scientific and Technological Research Council of Turkey (TUBITAK), project number 110S103.en_US
dc.identifier.doi10.2174/1570164615666180905104543
dc.identifier.endpage135en_US
dc.identifier.issn1570-1646
dc.identifier.issn1875-6247
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85065029805en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.2174/1570164615666180905104543
dc.identifier.urihttps://hdl.handle.net/11616/98775
dc.identifier.volume16en_US
dc.identifier.wosWOS:000458615900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Proteomicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiveren_US
dc.subjectmass spectrometryen_US
dc.subjectorgan preservation solutionen_US
dc.subjectproteomicsen_US
dc.subjectliver transplantationen_US
dc.subjecthypothermiaen_US
dc.titleProteomic Analysis of Liver Preservation Solutions Prior to Liver Transplantationen_US
dc.typeArticleen_US

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