Evaluation of pulmonary artery stiffness and right ventricle functions in polycythemia vera patients by transthoracic echocardiography

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dc.authoridKaraca, Yücel/0000-0002-5184-5308;
dc.authorwosidKaraca, Yücel/AAA-4477-2022
dc.authorwosidUlutaş, Zeynep/JMB-6092-2023
dc.contributor.authorKaraca, Yuecel
dc.contributor.authorHidayet, Siho
dc.contributor.authorBayramoglu, Adil
dc.contributor.authorYildirim, Erkan
dc.contributor.authorBerber, Ilhami
dc.contributor.authorGuven, Fatih
dc.contributor.authorYigit, Yakup
dc.date.accessioned2024-08-04T20:53:22Z
dc.date.available2024-08-04T20:53:22Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroductionPolycythemia vera (PV) is known to be a subgroup of chronic myeloproliferative neoplasms and is recognized as a cause of pulmonary hypertension (PH). Pulmonary artery stiffness (PAS) is a relatively new noninvasive echocardiographic index developed to evaluate the structural features and functions of the pulmonary vascular bed. In this study, we aimed to evaluate right ventricular (RV) functions and PAS in PV patients and healthy controls. MethodsA group of 65 consecutive PV patients and 40 healthy controls were included in the study. RV global longitudinal strain (RVGLS) and RV free wall longitudinal strain were (RVFwLS) evaluated using two-dimensional (2D) strain echocardiography. RV volume, systolic and diastolic functions were evaluated with three-dimensional (3D) echocardiography. PAS was calculated using the maximum frequency shift (MFS) and acceleration time of the pulmonary artery flow trace. ResultsPAS values were significantly higher in the PV group than in the control group (25.2 +/- 5.2 vs. 18.2 +/- 4.2, p < .001). We found that tricuspid annular plane systolic excursion (TAPSE) (p < .001), RV fractional area change (p < .001) and RV ejection fraction (p < .001) measurements evaluated by 3D echocardiography were significantly lower in the PV group. ConclusionIn our study, PAS values were higher in PV patients than in the healthy control group. Patients with PV may have subclinical RV dysfunction, and PAS value can be used in the early diagnosis of PH and RV dysfunction in this patient group.en_US
dc.identifier.doi10.1111/echo.15520
dc.identifier.endpage203en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue3en_US
dc.identifier.pmid36647760en_US
dc.identifier.scopus2-s2.0-85146318558en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage196en_US
dc.identifier.urihttps://doi.org/10.1111/echo.15520
dc.identifier.urihttps://hdl.handle.net/11616/101119
dc.identifier.volume40en_US
dc.identifier.wosWOS:000913618800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthree-dimensional echocardiographyen_US
dc.subjectpolycythemia veraen_US
dc.subjectpulmonary artery stiffnessen_US
dc.subjectright ventricular functionen_US
dc.titleEvaluation of pulmonary artery stiffness and right ventricle functions in polycythemia vera patients by transthoracic echocardiographyen_US
dc.typeArticleen_US

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