Caffeic acid phenethyl ester to inhibit posterior capsule opacification in rabbits

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dc.authoridGultek, Ahmet/0000-0002-4980-1568
dc.authoridBayramlar, Huseyin/0000-0002-8118-1151;
dc.authorwosidGultek, Ahmet/AAG-5735-2019
dc.authorwosidBayramlar, Huseyin/I-5876-2013
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.contributor.authorHepsen, IF
dc.contributor.authorBayramlar, H
dc.contributor.authorGultek, A
dc.contributor.authorOzen, S
dc.contributor.authorTilgen, F
dc.contributor.authorEvereklioglu, C
dc.date.accessioned2024-08-04T20:11:55Z
dc.date.available2024-08-04T20:11:55Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To assess whether caffeic acid phenethyl ester (CAPE) prevents posterior capsule opacification (PCO) by suppressing the transformation of the lens epithelial cells. Setting: Departments of Ophthalmology, Chemistry, and Pathology, Turgut Ozal Medical Center, University of Inonu, Malatya, Turkey. Methods: Twenty pigmented island rabbits having phacoemulsification in their right eyes were randomized into two groups. In Group 1, 10 mu g/ml of CAPE was added to the anterior chamber irrigating solution and a 1% solution of CAPE was injected subconjunctivally for 3 weeks postoperatively. The irrigating solution in Group 2 (control) did not include CAPE. The development of PCO was assessed weekly and its density was graded by slitlamp biomicroscopy. Histologic analysis was performed 3 months after surgery. Results: Group I had clear capsules or minor PCO. Group 2 developed more severe PCO or complete opacification. The difference between the two groups was statistically significant (P = .04). Conclusion: These preliminary results indicate that CAPE is effective in suppressing PCO in pigmented rabbits and may be beneficial in clinical use in humans because it has no documented harmful effects on normal cells.en_US
dc.identifier.doi10.1016/S0886-3350(97)80031-4
dc.identifier.endpage1576en_US
dc.identifier.issn0886-3350
dc.identifier.issn1873-4502
dc.identifier.issue10en_US
dc.identifier.pmid9456418en_US
dc.identifier.scopus2-s2.0-0031440622en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1572en_US
dc.identifier.urihttps://doi.org/10.1016/S0886-3350(97)80031-4
dc.identifier.urihttps://hdl.handle.net/11616/93094
dc.identifier.volume23en_US
dc.identifier.wosWOS:000071382200030en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Cataract and Refractive Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEthanolic Extracten_US
dc.subjectPropolis Extracten_US
dc.subjectCellsen_US
dc.subjectLensen_US
dc.subjectToxicityen_US
dc.subjectInvitroen_US
dc.subjectCapeen_US
dc.subjectPropertyen_US
dc.titleCaffeic acid phenethyl ester to inhibit posterior capsule opacification in rabbitsen_US
dc.typeArticleen_US

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