The mechanical or electrical induction of medullary angiogenesis: Will it improve sternal wound healing?

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dc.authorscopusid56614802600
dc.authorscopusid56249743200
dc.authorscopusid6508081411
dc.authorscopusid56636196100
dc.authorscopusid6506772736
dc.authorscopusid55907740100
dc.authorscopusid7005174333
dc.contributor.authorAlat I.
dc.contributor.authorInan M.
dc.contributor.authorGurses I.
dc.contributor.authorKekilli E.
dc.contributor.authorGermen B.
dc.contributor.authorHarma A.
dc.contributor.authorEskin A.
dc.date.accessioned2024-08-04T19:59:31Z
dc.date.available2024-08-04T19:59:31Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe induced angiogenesis in the tibial medulla and cortex of rabbits by electrical and mechanical stimulation, with the aim of future application to ischemic disease. Sixteen New Zealand rabbits were divided into 4 groups: in Group 1, a K wire was inserted into the medullary channel; in Group 2, a hole was drilled into the tibia; in Group 3, electrical stimulation was applied to the medullary channel; and in Group 4 (the control group), nothing was done. The interventions were applied during a 21-day period, after which all animals were evaluated scintigraphically and histopathologically. All 3 interventional groups were significantly superior to the control group in regard to medullary and cortical vascularity: the P values were 0.021 in all comparisons to control. However, the most fibrotic changes in the medulla occurred in the group that had been treated with electricity (P=0.008). Slight fibrotic changes occurred in the hole group (P=0.040), and none occurred in the K-wire group. In sum, all 3 interventions are capable of inducing medullary angiogenesis, but electricity is inferior in regard to fibrotic change. We believe that this present study can establish a baseline for further work that explores clinical applications to problematic ischemic conditions, including delayed sternal wound healing after cardiac surgery.en_US
dc.identifier.endpage367en_US
dc.identifier.issn0730-2347
dc.identifier.issue4en_US
dc.identifier.pmid15745286en_US
dc.identifier.scopus2-s2.0-10344239920en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://hdl.handle.net/11616/90687
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTexas Heart Institute Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectBone regenerationen_US
dc.subjectElectric stimulation therapyen_US
dc.subjectNeovascularization, physiologicen_US
dc.subjectSternum/blood supplyen_US
dc.subjectSurgical wound dehiscence/prevention & controlen_US
dc.subjectWound healing/physiologyen_US
dc.titleThe mechanical or electrical induction of medullary angiogenesis: Will it improve sternal wound healing?en_US
dc.typeArticleen_US

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