Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus

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dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691;
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidYILMAZ, Ercan/AAA-1818-2021
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorCiftci, Osman
dc.contributor.authorCelik, Ebru
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorBastemur, Ayse G.
dc.date.accessioned2024-08-04T20:45:40Z
dc.date.available2024-08-04T20:45:40Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim To test the hypothesis that altered A Disintegrin and Metalloproteinase Domains with Thrombospondins motifs (ADAMTS) is implicated in the etiopathogenesis of gestational diabetes mellitus (GDM). Methods All pregnant women who underwent elective amniocentesis for karyotype analysis between January 1, 2016, and January 1, 2018, were included in this study. From this cohort, the study group consisting of 20 patients diagnosed with GDM was selected and compared against a control group consisting of 20 age- and body mass index (BMI)-matched patients without GDM. ADAMTS4, ADAMTS5, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) levels were compared in the second trimester amniotic fluid of patients with GDM and normoglycemic pregnant women. Results No significant differences were observed between GDM and control groups regarding age, BMI, gestational age at amniocentesis and indication for amniocentesis. Mean amniotic fluid ADAMTS4 and ADAMTS5 levels were significantly increased in the GDM group compared with the control group (253.5 +/- 18.7 pg/mL and 188.5 +/- 21.3 pg/mL, P < 0.001; 192.9 +/- 16.4 pg/mL and 154.8 +/- 19.9 pg/mL, P = 0.021, respectively). Significant increases in IL-6 and TNF-alpha levels were also detected in the amniotic fluid of GDM patients relative to controls (136.2 +/- 17.3 pg/mL and 98.3 +/- 11.5 pg/mL, P < 0.001; 154.2 +/- 12.5 pg/mL and 86.2 +/- 10.8 pg/mL, P < 0.001, respectively). Conclusion The data presented here suggest that increased levels of ADAMTS4, ADAMTS5, IL-6 and TNF-alpha may play an important role in the progression of GDM.en_US
dc.identifier.doi10.1111/jog.13914
dc.identifier.endpage829en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue4en_US
dc.identifier.pmid30623540en_US
dc.identifier.scopus2-s2.0-85059669961en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage824en_US
dc.identifier.urihttps://doi.org/10.1111/jog.13914
dc.identifier.urihttps://hdl.handle.net/11616/98603
dc.identifier.volume45en_US
dc.identifier.wosWOS:000462919100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectA Disintegrin and Metalloprotease Proteinen_US
dc.subjectamnionen_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectinterleukin-6en_US
dc.subjectthrombospondinen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.titleEvaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitusen_US
dc.typeArticleen_US

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