Adrenomedullin Reduces Antioxidant Defense System and Enhances Kidney Tissue Damage in Cadmium and Lead Exposed Rats

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridFen Bilgisi Eğitimi, Aksaray Eğitim/0000-0001-8976-571X
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidFen Bilgisi Eğitimi, Aksaray Eğitim/B-4394-2014
dc.contributor.authorYurekli, Muhittin
dc.contributor.authorEsrefoglu, M.
dc.contributor.authorDogru, M. Ilker
dc.contributor.authorDogru, Arzu
dc.contributor.authorGul, M.
dc.contributor.authorWhidden, M.
dc.date.accessioned2024-08-04T20:31:15Z
dc.date.available2024-08-04T20:31:15Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAdrenomedullin (AdM) is synthesized and secreted by a number of cells and tissue. AdM is a potent vasodilator but it is also considered a neuromodulator, an angiogenic factor, and a hormone regulator. AdM possess antiapoptotic, antioxidant, and antimicrobial properties. Heavy metals such as cadmium and lead are found widely in the environment and they have important biological functions. Lead (Pb) and cadmium (Cd) can accumulate in the lungs, liver, bone, and kidneys and cause serious organ damage. In the present study, we investigated the effect of AdM, Pb + AdM, and Cd + AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney. Heavy metal accumulation was determined in kidney with and without AdM infusion and kidney damage was evaluated by light and electron microscopy. Increased heavy metal accumulation was observed in the heavy metal and AdM treated groups. SOD, CAT, GSH-Px activities, and MDA levels were significantly different in the treatment groups when compared with the control group. Tubular degeneration, necrosis, cell swelling, mononuclear cell infiltration, and degenerated organelles were observed in the kidney following treatment. Therefore, AdM infusion has no beneficial and/or compensatory role in cadmium and lead toxicity in the kidney. We conclude that heavy metal accumulation in the kidney in conjunction with AdM infusion is cytotoxic despite the known beneficial effects of adrenomedullin. (C) 2008 Wiley Periodicals, Inc. Environ Toxicol 24: 279-286, 2009.en_US
dc.identifier.doi10.1002/tox.20430
dc.identifier.endpage286en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue3en_US
dc.identifier.pmid18655190en_US
dc.identifier.scopus2-s2.0-66749157390en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org/10.1002/tox.20430
dc.identifier.urihttps://hdl.handle.net/11616/94808
dc.identifier.volume24en_US
dc.identifier.wosWOS:000265967200008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEnvironmental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectSODen_US
dc.subjectCATen_US
dc.subjectGSH-Pxen_US
dc.subjectlight and electron microscopyen_US
dc.subjectheavy metalsen_US
dc.titleAdrenomedullin Reduces Antioxidant Defense System and Enhances Kidney Tissue Damage in Cadmium and Lead Exposed Ratsen_US
dc.typeArticleen_US

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