Predictors of splenectomy response in patients with immune thrombocytopenia

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dc.authoridSimsek, Arife/0000-0002-4807-3597
dc.authoridDOGAN, SAIT MURAT/0000-0001-8840-4365
dc.authorwosidSimsek, Arife/AAB-3245-2021
dc.authorwosidDOGAN, SAIT MURAT/AAP-7924-2021
dc.contributor.authorSimsek, A.
dc.contributor.authorDogan, S. M.
dc.date.accessioned2024-08-04T20:49:17Z
dc.date.available2024-08-04T20:49:17Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE To evaluate the predictors of the response to splenectomy in patients with immune thrombocytopenia. METHOD The medical records were reviewed retrospectively of patients who had undergone total splenectomy for immune thrombocytopenia at a tertiary center between January 2009 and December 2019. RESULTS This study included 40 patients (28 females and 12 males) with immune thrombocytopenia. A complete response was obtained in 31 (77.5%) patients, with 9 (22.5%) patients failing to respond to splenectomy. The response was stable in 25 patients (62.5%), and 5 patients (12.5%) had a recurrence. The postoperative mortality rate was 2.5%; one patient developed an ischemic stroke and died. Multivariate analysis demonstrated that an extended time from diagnosis to splenectomy, a lower demand for transfusion of blood components, and a shorter length of hospitalization were positively associated with a complete response. CONCLUSIONS Splenectomy should be considered as the therapeutic approach to immune thrombocytopenia, with a high curative potential in suitable patients. An extended time from diagnosis to splenectomy, lower demand for transfusion of blood components, and shorter length of hospitalization were found to be positively associated with a complete response after splenectomy.en_US
dc.identifier.endpage54en_US
dc.identifier.issn1105-3992
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85100738108en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://hdl.handle.net/11616/99760
dc.identifier.volume38en_US
dc.identifier.wosWOS:000644672200007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAthens Medical Socen_US
dc.relation.ispartofArchives of Hellenic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmune thrombocytopeniaen_US
dc.subjectITPen_US
dc.subjectPrognosisen_US
dc.subjectRelapseen_US
dc.subjectSplenectomyen_US
dc.subjectSplenectomy responseen_US
dc.titlePredictors of splenectomy response in patients with immune thrombocytopeniaen_US
dc.typeArticleen_US

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