Protective effect of saxagliptin against renal ischaemia reperfusion injury in rats

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dc.authoridCakir, Murat/0000-0002-2066-829X
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridTekin, Çiğdem/0000-0001-9038-1924
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authorwosidCakir, Murat/I-8643-2019
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidErden, Yavuz/AAJ-7783-2021
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidErden, Yavuz/IZE-2291-2023
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidTekin, Çiğdem/ABI-5395-2020
dc.contributor.authorTekin, Suat
dc.contributor.authorBeytur, Asiye
dc.contributor.authorCakir, Murat
dc.contributor.authorTaslidere, Ash
dc.contributor.authorErden, Yavuz
dc.contributor.authorTekin, Cigdem
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:47:05Z
dc.date.available2024-08-04T20:47:05Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSaxagliptin is an effective and selective dipeptidyl peptidase-4 (DPP-4) inhibitor. This study was designed to determine possible protective effects of saxagliptin against damage caused by renal ischaemia/reperfusion (I/R) in rats. In this study, 40 rats were divided into 4 groups (n = 10 for each). Group 1 (Control), Group 2 (I/R) in both kidneys ischaemia of 45 min was performed, and then reperfusion was applied for 24 h. Saxagliptin (Group 3: 2 mg/kg and Group 4: 10 mg/kg) was administered by oral gavage to the animals in treatment groups, before the I/R. Saxagliptin decreased the markers (BUN, Cre, NGAL, KIM-1 and IL-18) of acute renal damage in blood and kidney tissue. Saxagliptin provided increase in antioxidant enzyme levels and decrease in MDA and apoptosis. Histological results showed that the administration of saxagliptin exhibited a protective effect against renal damage caused by I/R. These results indicates that saxagliptin provide protection against kidney injury caused by I/R.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Fund [TCD-2017-647]en_US
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Projects Fund [Project #TCD-2017-647].en_US
dc.identifier.doi10.1080/13813455.2020.1715442
dc.identifier.endpage618en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue3en_US
dc.identifier.pmid31979992en_US
dc.identifier.scopus2-s2.0-85078474005en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage608en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2020.1715442
dc.identifier.urihttps://hdl.handle.net/11616/99159
dc.identifier.volume128en_US
dc.identifier.wosWOS:000509173800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDipeptidyl peptidase-4 inhibitoren_US
dc.subjectoxidative stressen_US
dc.subjectsaxagliptinen_US
dc.subjectrenal ischaemia reperfusionen_US
dc.subjectlipid peroxidationen_US
dc.titleProtective effect of saxagliptin against renal ischaemia reperfusion injury in ratsen_US
dc.typeArticleen_US

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