Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats

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dc.authoridGultek, Ahmet/0000-0002-4980-1568
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidGultek, Ahmet/AAG-5735-2019
dc.authorwosidUz, Efkan/B-2943-2016
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidAYDIN, Nasuhi/O-9043-2016
dc.contributor.authorKoltuksuz, U
dc.contributor.authorÖzen, S
dc.contributor.authorUz, E
dc.contributor.authorAydinç, M
dc.contributor.authorKaraman, A
dc.contributor.authorGültek, A
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-08-04T20:12:00Z
dc.date.available2024-08-04T20:12:00Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Purpose: Ischemia-reperfusion injury is encountered frequently in conditions that diminish intestinal blood flow. Caffeic acid phenethyl ester (CAPE), which is a specific component of the honeybee hive product propolis, exhibits potential antioxidant: properties. This experimental study was designed to determine the effect of CAFE on ischemia-reperfusion injury in rat intestine. Methods: Fifty rats were divided into 5 groups: sham (SH), saline ischemia (SI), saline reperfusion (SR), CARE ischemia (CI), and CARE reperfusion (CR). Either CAFE, 10 mu mol/kg, or saline was administered intraperitoneally 30 minutes before ischemia. Intestinal ischemia for 30 minutes and reperfusion for 60 minutes were applied. Ileum specimens were obtained to determine the tissue levels of malondialdehyde, superoxide dismutase, catalase, and histological changes. Results Malondialdehyde levels in the CR group did not increase after reperfusion when compared with the CI group. However, statistically significant differences were observed between the SR and SI groups. Additional mucosal injury in the CR group when compared with the CI group was not observed. Whereas, there was a statistically significant increase in mucosal injury in the SR group. Reperfusion did not cause further injuries through both biochemical and histological parameters in the CR group. Conclusions: Results of this study showed that prophylactic administration of CAFE in ischemic condition prevents reperfusion injuries by eliminating oxygen radicals and inhibiting polymorphonuclear leukocyte infiltration. CARE may be useful in combating the diseases of oxidative stress. J Pediatr Surg 34:1458-1462. Copyright (C) 1999 by W.B. Saunders Company.en_US
dc.identifier.doi10.1016/S0022-3468(99)90103-3
dc.identifier.endpage1462en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue10en_US
dc.identifier.pmid10549747en_US
dc.identifier.scopus2-s2.0-0032741772en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1458en_US
dc.identifier.urihttps://doi.org/10.1016/S0022-3468(99)90103-3
dc.identifier.urihttps://hdl.handle.net/11616/93150
dc.identifier.volume34en_US
dc.identifier.wosWOS:000083310700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintestinal ischemiaen_US
dc.subjectreperfusionen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectlipid peroxidationen_US
dc.subjectantioxidant enzymesen_US
dc.titleCaffeic acid phenethyl ester prevents intestinal reperfusion injury in ratsen_US
dc.typeArticleen_US

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