Assessment of novel biomarkers: STREM-1, pentraxin-3 and pro-adrenomedullin in the early diagnosis of neonatal early onset sepsis

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dc.authorscopusid22836749900
dc.authorscopusid55114329200
dc.authorscopusid7003301157
dc.authorscopusid23990146900
dc.authorscopusid14318941200
dc.authorscopusid35602207700
dc.authorscopusid35595823600
dc.contributor.authorTunç T.
dc.contributor.authorPolat A.
dc.contributor.authorÖzdemir R.
dc.contributor.authorKiliçaslan B.
dc.contributor.authorCan E.
dc.contributor.authorÇelik H.T.
dc.contributor.authorArsan S.
dc.date.accessioned2024-08-04T20:03:29Z
dc.date.available2024-08-04T20:03:29Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Early onset bacterial sepsis in neonates (EOS) is recognized as an important health condition. Early diagnosis is crucial. However, blood culture results are released in 48-72 hours. Many biomarkers have been investigated but none have been accepted as the gold standard. This study aimed to investigate the diagnostic value of the molecules: soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1), pentraxin-3 (PTX-3) and pro adrenomedullin (pro-ADM) in EOS and compare with currently used biomarkers. METHODS: In this multicenter prospective study, patients were enrolled from different NICUs around the Turkey. Patient data were collected via web-based registry system from attending centers. Neonates, hospitalized with a suspicion of EOS were enrolled. Blood culture and routine blood tests were collected and a serum sample was obtained and kept in-80°C for studying the molecules. According to laboratory results, patients were divided into three groups as; proven sepsis, clinical sepsis and control group. Groups were compared in terms of demographic, clinical and laboratory findings. The primary outcome of the study was to assess any difference between groups in terms of the diagnostic value of the markers aforementioned. RESULTS: A total of 130 patients were enrolled; proven sepsis (n = 36), clinical sepsis (n = 53) and control (n = 41) groups. Groups were similar in terms of demographic findings; mean WBC (P = 0.445), procalcitonin (PCT) (P = 0.083) and IL-6 (P = 0.814) levels. Mean C-reactive protein (CRP) level was significantly higher in clinical sepsis and proven sepsis groups compared to control group (P < 0.001). Mean PTX-3 (P = 0.547), pro-ADM (P = 0.766) and sTREM-1 (P = 0.838) levels were similar between groups. CONCLUSION: These promising molecules failed to help in early diagnosis of EOS. Their relation to correlation with disease progression may make more sense as they seem to be expressed in higher amounts with the progression of the disease in previous studies. CRP was the most frequently used biomarker for detecting the sepsis in our study population. © 2020-IOS Press and the authors. All rights reserved.en_US
dc.description.sponsorshipOur study was funded and supported by Turkish Neonatal Society.en_US
dc.identifier.doi10.3233/NPM-180131
dc.identifier.endpage45en_US
dc.identifier.issn1934-5798
dc.identifier.issue1en_US
dc.identifier.pmid31594258en_US
dc.identifier.scopus2-s2.0-85083371269en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.3233/NPM-180131
dc.identifier.urihttps://hdl.handle.net/11616/91843
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIOS Pressen_US
dc.relation.ispartofJournal of Neonatal-Perinatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectneonatal early onset sepsisen_US
dc.subjectpentraxin-3en_US
dc.subjectpro-ADMen_US
dc.subjectsTREM-1en_US
dc.titleAssessment of novel biomarkers: STREM-1, pentraxin-3 and pro-adrenomedullin in the early diagnosis of neonatal early onset sepsisen_US
dc.typeArticleen_US

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