DOSE DEPENDENT EFFECTS OF CAFFEIC ACID PHENETHYL ESTER ON HEART RATE AND BLOOD PRESSURE IN RATS

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoriderdogan, selim/0000-0002-9169-9771
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosiderdogan, selim/AAT-2487-2020
dc.contributor.authorIraz, Mustafa
dc.contributor.authorFadillioglu, Ersin
dc.contributor.authorTasdemir, Seda
dc.contributor.authorAtes, Burhan
dc.contributor.authorErdogan, Selim
dc.date.accessioned2024-08-04T20:15:07Z
dc.date.available2024-08-04T20:15:07Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis and its structure is similar to flavonoids. The molecular mechanisms of the effects of CAPE on various systems including cardiovascular system have not been known well. The aim of the present study was to investigate the short term dose dependent in vivo cardiovascular effects including heart rate and blood pressure changes induced by CAPE in Sprague Dawley rats. Methods: The rats were anaesthetized and randomly divided into six groups (n: 6 rats) as follows: the first two groups of rats were injected 0.9% NaCl or 10% alcohol; the other groups were injected 1 mg kg(-1), 5 mg kg(-1) 10 mg kg(-1) or 20 mg kg(-1) CAPE i.v. Results: CAPE injection caused decrease in mean blood pressure (MBP) up to 20 sec. for 1 mg CAPE group and up to 2 min for 5 and 10 mg CAPE groups. On the other hand, heart rate (HR) was found to be decreased up to 10 min. for 10 mg CAPE group Conclusion: CAPE causes decrease in both HR and MBP and may affect conduction velocity and contractility in heart due to possible effects on neuronal transmission.en_US
dc.identifier.doi10.29333/ejgm/82272
dc.identifier.endpage75en_US
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-28844502463en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.29333/ejgm/82272
dc.identifier.urihttps://hdl.handle.net/11616/94183
dc.identifier.volume2en_US
dc.identifier.wosWOS:000421855400005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherModestum Ltden_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaffeic acid phenethyl ester (CAPE)en_US
dc.subjectbradycardiaen_US
dc.subjecthypotensionen_US
dc.subjectraten_US
dc.titleDOSE DEPENDENT EFFECTS OF CAFFEIC ACID PHENETHYL ESTER ON HEART RATE AND BLOOD PRESSURE IN RATSen_US
dc.typeArticleen_US

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