Examination of the antioxidant effects of pre-HSG melatonin use on ovarian surface epithelium in rats: An experimental study

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dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117;
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidKocamaz, Derya/U-9743-2018
dc.authorwosidSapmaz, Tansel/JMQ-6337-2023
dc.contributor.authorYilmaz, Esra Saygili
dc.contributor.authorSapmaz, Tansel
dc.contributor.authorKazgan, Halil
dc.contributor.authorYildiz, Sule Menziletoglu
dc.contributor.authorKocamaz, Derya
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorSapmaz, Ekrem
dc.date.accessioned2024-08-04T20:45:22Z
dc.date.available2024-08-04T20:45:22Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground.There is no study of whether the dysplastic changes in the ovarian surface epithelium of X-ray-exposed rats during hysterosalpingography (HSG) decrease or not with the use of Lipiodol and melatonin given both intiaperitoneally (i.p.) and into the suspensorium ovarii. Objectives. We investigated the restorative effects of melatonin and Lipiodol admimstiation during the HSG piocedure on the dysplastic changes in the ovarian surface epithelium of X-ray-exposed rats. Material and methods. A total of 50 Wistar rats with regular estrous cycles were randomly divided into 5 groups. Group 1 was the control group. In other groups, X-ray was applied (group 2), 0.1 mL Lipiodol was applied to each uterine horn (group 3),20 mg/kg intraperitoneal melatonin application was followed by 0.1 mL Lipiodol administration to each uterine horn after 15 min (group 4), and 20 mg/kg melatonin was administered to the ligamentum suspensorium ovarii, followed by 0.1 mL Lipiodol application to each uterine horn after 15 min (group 5). The rats in groups 2-5 were exposed to whole body radiation 3 times. After 3 h, the abdomens of all rats were reopened and left oophorectomy was performed. Results. The presence of nucleoli and mitosis values were found similar among the groups. All other palameters were significantly higher in group 2 compated to other groups, except for the presence of nucleoli and mitosis values (p < 0.05). The presence of hyperchromasia and the total score were found to be the highest in group 2, followed by group 3, when compared to other groups (p < 0.05). It was detected that the detrimental effects of X-iay exposure diminished with Lipiodol use, and were further reduced by the use of melatonin in combination. Conclusions. We suggest that the use of melatonin and Lipiodol during HSG may prevent the carcinogenic changes exeited by radiation on the ovarian suiface epithelium.en_US
dc.identifier.doi10.17219/acem/70810
dc.identifier.endpage911en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue7en_US
dc.identifier.pmid29952147en_US
dc.identifier.scopus2-s2.0-85051415120en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage907en_US
dc.identifier.urihttps://doi.org/10.17219/acem/70810
dc.identifier.urihttps://hdl.handle.net/11616/98426
dc.identifier.volume27en_US
dc.identifier.wosWOS:000440357400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmelatoninen_US
dc.subjecthysterosalpingographyen_US
dc.subjectratsen_US
dc.subjectradiationen_US
dc.subjectLipiodolen_US
dc.titleExamination of the antioxidant effects of pre-HSG melatonin use on ovarian surface epithelium in rats: An experimental studyen_US
dc.typeArticleen_US

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