Nobel's harvest in Türkiye: Delving into Artemisia's spirit - essential oil content and antimicrobial potential of seven species

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dc.authorid0000-0002-0243-3454
dc.authorid0000-0002-3998-8859
dc.authorid0000-0001-8531-9130
dc.contributor.authorOsmanlıoğlu Dağ, Şüheda Rumeysa
dc.contributor.authorÖztürk, Gözde
dc.contributor.authorTatlı Çankaya, İffet İrem
dc.date.accessioned2026-02-11T08:54:22Z
dc.date.available2026-02-11T08:54:22Z
dc.date.issued2024
dc.departmentFakülteler, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü
dc.descriptionThe 2015 Nobel Prize in Physiology or Medicine was awarded due to the isolation of the active ingredient of artemisinin, a sesquiterpene lactone, from the plant Artemisia annua L. and proving its effectiveness in the treatment of malaria, and the chemical contents and biological activities of other Artemisia L. species aroused great interest. In this study, it was aimed to investigate the chemical content of essential oils obtained by hydrodistillation from the aerial parts of seven Artemisia species (A. abrotanum L., A. absinthium L., A. annua L., A. austriaca Jacq., A. chamaemelifolia Vill., A. incana (L.) Druce, A. tournefortiana Rchb.) growing in different regions of Turkiye and to evaluate their antimicrobial activities. The essential oils were analyzed by GC and GC-MS. The main components are chrysanthenone (55.9%) for A. abrotanum, sabinyl acetate (23.0%) for A. absinthium, artemisia ketone (53.7%) for A. annua, camphor (34.2%) for A. austriaca, selin-11-en-4-?-ol (29.1%) for A. chamaemelifolia, camphor (29.7%) for A. incana, and (Z)-ß-farnesene (71.5%) for A. tournefortiana. In vitro antimicrobial activity of essential oils against five microorganisms (Bacillus subtilis, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, Pseudomonas aeruginosa) was investigated using the microdilution method. The highest activity against all species was observed in A. incana essential oil. Staphylococcus aureus was found to be the most sensitive bacteria to all essential oils.
dc.description.abstractThe 2015 Nobel Prize in Physiology or Medicine was awarded due to the isolation of the active ingredient of artemisinin, a sesquiterpene lactone, from the plant Artemisia annua L. and proving its effectiveness in the treatment of malaria, and the chemical contents and biological activities of other Artemisia L. species aroused great interest. In this study, it was aimed to investigate the chemical content of essential oils obtained by hydrodistillation from the aerial parts of seven Artemisia species (A. abrotanum L., A. absinthium L., A. annua L., A. austriaca Jacq., A. chamaemelifolia Vill., A. incana (L.) Druce, A. tournefortiana Rchb.) growing in different regions of Turkiye and to evaluate their antimicrobial activities. The essential oils were analyzed by GC and GC-MS. The main components are chrysanthenone (55.9%) for A. abrotanum, sabinyl acetate (23.0%) for A. absinthium, artemisia ketone (53.7%) for A. annua, camphor (34.2%) for A. austriaca, selin-11-en-4-?-ol (29.1%) for A. chamaemelifolia, camphor (29.7%) for A. incana, and (Z)-ß-farnesene (71.5%) for A. tournefortiana. In vitro antimicrobial activity of essential oils against five microorganisms (Bacillus subtilis, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, Pseudomonas aeruginosa) was investigated using the microdilution method. The highest activity against all species was observed in A. incana essential oil. Staphylococcus aureus was found to be the most sensitive bacteria to all essential oils.
dc.identifier.citationDAĞ, Ş. R. O., OZTURK, G., ÇANKAYA, İ. İ. T., KURŞAT, M., DEMIRCI, B., OZKAN, A. M. G. (2024). Nobel's harvest in Türkiye: Delving into Artemisia's spirit - essential oil content and antimicrobial potential of seven species. Journal of research in pharmacy (online), 28(6),1936-1945. doi.org/10.29228/jrp.866
dc.identifier.endpage1945
dc.identifier.issue6
dc.identifier.startpage1936
dc.identifier.urihttps://hdl.handle.net/11616/106374
dc.identifier.volume28
dc.language.isoen
dc.publisherİnönü Üniversitesi
dc.relation.ispartofJournal of research in pharmacy (online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEssential oil
dc.subjectGC-MS
dc.subjectArtemisia
dc.subjectGC
dc.subjectAntimicrobial
dc.titleNobel's harvest in Türkiye: Delving into Artemisia's spirit - essential oil content and antimicrobial potential of seven species
dc.typeArticle

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