Is paracetamol responsible for fatal acute liver failure in pediatric patients after hip dysplasia surgery?

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dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridKarakaplan, Mustafa/0000-0001-9035-0319
dc.authoridOzkan, Ahmet Selim/0000-0002-4543-8853
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authorwosidceylan, mehmet fethi/ABF-1126-2020
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidKarakaplan, Mustafa/IXN-3318-2023
dc.authorwosidOzkan, Ahmet Selim/ABH-2918-2020
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.contributor.authorCeylan, M. F.
dc.contributor.authorBaskiran, A.
dc.contributor.authorVarol, F., I
dc.contributor.authorSamdanci, E. T.
dc.contributor.authorKarakaplan, M.
dc.contributor.authorOzkan, A. S.
dc.date.accessioned2024-08-04T20:49:04Z
dc.date.available2024-08-04T20:49:04Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: It is well known that local complications, such as avascular necrosis and arthrosis can develop after surgery for developmental dysplasia of the hip (DDH). Thus far, systemic complications that may develop in such cases have not been identified in the literature. This study is the first case series to evaluate acute liver failure (ALF) development after DDH surgery in pediatric patients. PATIENTS AND METHODS: Six patients, five female and one male. who underwent DDH surgery were selected for this study. Perioperative fasting time. laboratory values, treatments. histopathological evaluations, and prognoses after ALF in these patients were evaluated retrospectively. RESULTS: All the patients were administered paracetamol and sevoflurane in therapeutic doses. The patients were referred postoperatively to our pediatric emergency department after 5 +/- 1.67 days (range = 3-7 days) on average. The average perioperative fasting time was 9.3 +/- 0.82 hours (range = 8-10 hours). Due to the very high aminotransferases and use of paracetamol, intravenous N-acetylcysteine was administered alongside supportive treatments to all the patients. After liver transplantation, two of three patients with grade 3 encephalopathy, died in the early postoperative period. Histopathological evaluations of the three patients' explants were compatible with toxic hepatitis due to paracetamol. CONCLUSIONS: Paracetamol is a commonly used analgesic after pediatric surgery. The therapeutic dose of paracetamol remains uncertain in children who have been fasting for a long time and have been exposed to hepatotoxic drugs due to previous surgery. In conclusion, caution should be exercised in the use of paracetamol in children with DDH who will undergo surgery, and careful perioperative clinical and laboratory monitoring for ALF is essential.en_US
dc.identifier.doi10.26355/eurrev_202010_23441
dc.identifier.endpage10811en_US
dc.identifier.issn1128-3602
dc.identifier.issue20en_US
dc.identifier.pmid33155241en_US
dc.identifier.scopus2-s2.0-85095763015en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage10806en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202010_23441
dc.identifier.urihttps://hdl.handle.net/11616/99619
dc.identifier.volume24en_US
dc.identifier.wosWOS:000585086700068en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDevelopmental dysplasiaen_US
dc.subjectParacetamol toxicityen_US
dc.subjectEncephalopathyen_US
dc.subjectHistopathological evaluationen_US
dc.titleIs paracetamol responsible for fatal acute liver failure in pediatric patients after hip dysplasia surgery?en_US
dc.typeArticleen_US

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