Effects of Local and Systemic Zoledronic Acid Application on Titanium Implant Osseointegration: An Experimental Study Conducted on Two Surface Types

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dc.authoridKARAMAN, TAHİR/0000-0002-3764-637X
dc.authoridKIRTAY, Mustafa/0000-0003-2568-7470
dc.authorwosidDundar, Serkan/V-8159-2018
dc.authorwosidKARAMAN, TAHİR/V-8392-2018
dc.authorwosidCakmak, Omer/W-4556-2017
dc.authorwosidKIRTAY, Mustafa/ABA-7066-2021
dc.contributor.authorDundar, Serkan
dc.contributor.authorYaman, Ferhan
dc.contributor.authorGecor, Orhan
dc.contributor.authorCakmak, Omer
dc.contributor.authorKirtay, Mustafa
dc.contributor.authorYildirim, Tuba Talo
dc.contributor.authorKaraman, Tahir
dc.date.accessioned2024-08-04T20:43:00Z
dc.date.available2024-08-04T20:43:00Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effects of local and systemic zoledronic acid (ZA) applications on titaniumoksit ceramic blasted (TiO-CB)- and sandblasted large acid-grit (SLA)-surfaced titanium implant osseointegration. Twelve New Zealand White rabbits were used in the study, divided into 6 groups: the TiO-CB (TiO-CB-CNT) (n = 2) and SLA (SLA-CNT) (n = 2) control groups in which TiO-CB- and SLA-surfaced titanium implants were surgically inserted into rabbit tibias but no treatment was applied; the TiO-CB (TiO-CB-LZA) (n = 2) and SLA (SLA-LZA) (n = 2) local ZA groups in which 1 mL of normal saline solution containing 2 mg of ZA was injected into sockets and after this the implants were integrated; and the TiO-CB (TiO-CB-SZA) (n = 2) and SLA (SLA-SZA) (n = 2) systemic ZA groups in which a single infusion of 0.1 mg/kg of ZA was administered during surgical implant insertion. Following a period of osseointegration, bone implant contact (BIC) was recorded as a proportion of the total implant surface length in direct contact with the bone. Results of this study indicate that BIC was greater in the systemic ZA application groups than in the local ZA application groups, and BIC was greater in the local ZA groups than in the controls. Statistically significant differences in BIC were not detected between the TiO-CB- and SLA-surfaced implants in all the groups. Furthermore, this study did not reveal significant differences between the 2 types of surfaces due to similar average roughness values. Overall, systemic ZA application was found to be more effective in increasing BIC than local ZA application based on the results obtained by testing 2 implant surfaces.en_US
dc.description.sponsorshipFirat University Scientific Research Project Foundation Department [DHF.15.01]en_US
dc.description.sponsorshipThis study was supported by Firat University Scientific Research Project Foundation Department with the project number DHF.15.01.en_US
dc.identifier.doi10.1097/SCS.0000000000003568
dc.identifier.endpage938en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue4en_US
dc.identifier.pmid28230589en_US
dc.identifier.scopus2-s2.0-85013631401en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage935en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000003568
dc.identifier.urihttps://hdl.handle.net/11616/97703
dc.identifier.volume28en_US
dc.identifier.wosWOS:000402750600058en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone implant connectionen_US
dc.subjectosseointegrationen_US
dc.subjectrabbit tibiaeen_US
dc.subjectsurface roughingen_US
dc.subjectzoledronic aciden_US
dc.titleEffects of Local and Systemic Zoledronic Acid Application on Titanium Implant Osseointegration: An Experimental Study Conducted on Two Surface Typesen_US
dc.typeArticleen_US

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