The predictive value of maternal serum AFP to PAPP-A or b-hCG ratios in spontaneous preterm birth

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dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridKalkan, Üzeyir/0000-0001-5223-6697
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidKalkan, Üzeyir/AAZ-1545-2020
dc.contributor.authorCelik, Ebru
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorBaygul, Arzu
dc.contributor.authorKalkan, Uzeyir
dc.contributor.authorSimsek, Yavuz
dc.date.accessioned2024-08-04T20:51:59Z
dc.date.available2024-08-04T20:51:59Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe use of the second trimester alpha-fetoprotein (AFP) along with the first trimester pregnancy-associated plasma protein-A (PAPP-A) has been found to be useful in the estimation of unfavourable pregnancy outcome. Our aim in this study was to determine the relationship between maternal PAPP-A and b-hCG and AFP concentrations in spontaneous preterm birth (sPTB). This prospective cohort study included 372 singleton pregnancies with PAPP-A, b-hCG and AFP levels in the first trimester, which were converted to multiples of the median (MoM). The predictive ability of AFP-to-PAPP-A and AFP-to-b-hCG ratios for sPTB was evaluated. The risk for sPTB <= 34 weeks increased in women with AFP-to-PAPP-A ratio >7 (OR 2.9, 95% CI 1.2-6.4). Women with AFP-to-b-hCG ratio >0.6 had a 3.5-fold higher risk for sPTB <= 32 weeks. Increased maternal AFP-to-PAPP-A or AFP-to-b-hCG ratios in the first trimester may help to predict pregnant women at high risk for sPTB, and this may be beneficial in developing management plans.en_US
dc.identifier.doi10.1080/01443615.2022.2055452
dc.identifier.endpage1961en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue6en_US
dc.identifier.pmid35620869en_US
dc.identifier.scopus2-s2.0-85131167757en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1956en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2022.2055452
dc.identifier.urihttps://hdl.handle.net/11616/100684
dc.identifier.volume42en_US
dc.identifier.wosWOS:000801163600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreterm birthen_US
dc.subjectAFPen_US
dc.subjectPAPP-Aen_US
dc.subjectbeta-hCGen_US
dc.subjectmaternal biochemical markersen_US
dc.titleThe predictive value of maternal serum AFP to PAPP-A or b-hCG ratios in spontaneous preterm birthen_US
dc.typeArticleen_US

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