Efficacy of ticlopidine on platelet aggregability in patients with a VVI pacemaker
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Dosyalar
Tarih
1999
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İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: Birkaç çalışma VVI pacemakerlı hastalarda platelet agregabilitede bir artış olduğunu daha önceden saptamış idi; üstelik bazı yazarlar, bu hastalarda platelet aktivasyon belirteçlerinin artmış oluşumunu gösteren platelet agregasyonunun azalmasında antiplatelet ilaçların etkili olabildiğini gösterdi. Bu hususta, platelet agregabilite 25 VVI pacemaker hastasında ve 15 kontrol grubunda araştırıldı. Ayrıca, ?-thromboglobulin (Beta-TG) and platelet faktör 4 (PF4)'ün plazma düzeyleri tiklopidin tedavisi öncesi ve sonrası plateletlerin aktivasyon derecesini saptamak için ölçüldü. Plazma Beta-TG and PF4 düzeyleri kontrol grubuyla karşılaştırıldığında VVI'lı hastalarda önemli ölçüde artmış idi. (Sırasıyla, 147. 84±44.45, 75.64±31.77, P<0.001 ve 62.90±71.93, 21.88±11.10, P < 0.001). Ayrıca, tiklopidin tedavisi sonrası plazma Beta-TG ve PF4 düzeyleri tiklopidin tedavisi öncesindeki düzeylerle karşılaştırıldığında önemli oranda azalmış idi. (Sırasıyla, 43.69±16.56, 147.84±44.45, P < 0.001 ve 15.07±7.17, 62.90±71.93, P<0.001). Verilerimiz, VVI pacemakerlı hastalarda platelet agregabilitede bir artış olduğunu doğrulamakta ve platelet agregabiliteyi azaltmakta tiklopidinin etkili olduğunu göstermektedir.
Abstract: Several studies have previously reported an increased platelet aggregability in patients with VVI pacemakers; moreover, some authors have showed that antiplatelet drugs may be effective in reducing platelet aggregation, thus suggesting an increased formation of platelet activation markers in these patients. In this respect, platelet aggregability was investigated in twenty five VVI patients and fifteen control subjects. In addition, beta-thromboglobulin (Beta-TG) and platelet factor 4 (PF4) plasma levels were measured to determine the degree of platelet activation before and after ticlopidine treatment. Plasma Beta-TG and PF4 levels were significantly increased in VVI patients as compared with control subjects (147.84±44.15 vs 75.64±31.77, P<0.001 and 62.90±71.93 vs 21.88±11.10, p<0,001; respectively). Additionally, plasma Beta-TG and PF4 levels after ticlopidine treatment were significantly decreased as compared with that before ticlopidine treatment (43.69±16.56 vs 147.84±44.45, P<0.001 and 15.07±7.17 vs 62.90±71.93, P<0.001; respectively). Our data confirm an increased of platelet aggregability in patients with VVI pacemakers and show the efficacy of ticlopidine in reducing platelet aggregability.
Abstract: Several studies have previously reported an increased platelet aggregability in patients with VVI pacemakers; moreover, some authors have showed that antiplatelet drugs may be effective in reducing platelet aggregation, thus suggesting an increased formation of platelet activation markers in these patients. In this respect, platelet aggregability was investigated in twenty five VVI patients and fifteen control subjects. In addition, beta-thromboglobulin (Beta-TG) and platelet factor 4 (PF4) plasma levels were measured to determine the degree of platelet activation before and after ticlopidine treatment. Plasma Beta-TG and PF4 levels were significantly increased in VVI patients as compared with control subjects (147.84±44.15 vs 75.64±31.77, P<0.001 and 62.90±71.93 vs 21.88±11.10, p<0,001; respectively). Additionally, plasma Beta-TG and PF4 levels after ticlopidine treatment were significantly decreased as compared with that before ticlopidine treatment (43.69±16.56 vs 147.84±44.45, P<0.001 and 15.07±7.17 vs 62.90±71.93, P<0.001; respectively). Our data confirm an increased of platelet aggregability in patients with VVI pacemakers and show the efficacy of ticlopidine in reducing platelet aggregability.
Açıklama
Yıl: 1999Cilt: 6Sayı: 1ISSN: 1300-1744Sayfa Aralığı: 6 - 8Metin Dili:İngilizce
Anahtar Kelimeler
Kaynak
İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
1
Künye
KOŞAR F,OĞUZHAN A (1999). Efficacy of ticlopidine on platelet aggregability in patients with a VVI pacemaker. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 6(1), 6 - 8.
