Effect of cyclooxygenase-2 inhibition on nicotine-induced oxidative stress

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dc.authorscopusid26024440900
dc.authorscopusid6603643064
dc.contributor.authorÜnüvar S.
dc.contributor.authorAktay G.
dc.date.accessioned2024-08-04T19:59:40Z
dc.date.available2024-08-04T19:59:40Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe examined the tissue thiobarbituric acid reactive substances (TBARS), non-protein thiol (NP-SH) and total thiol (T-SH) group levels in order to deduce the role of cyclooxygenase-2 (COX-2) pathway on nicotine-induced oxidative tissue damage. Wistar Albino male rats were divided into three groups: Group I; 0.9% saline (ip), Group II; nicotine ditartarate (1.5 mg/kg, ip), Grup III; celecoxib (15 mg/kg, ip)+nicotine ditartarate (1.5 mg/kg ip). At the end of the 7th day, liver, lung, kidney, heart and brain tissues were removed. Nicotine treatment significantly increased TBARS, NP-SH and T-SH levels in all tissues. However, celecoxib treatment prior the nicotine injection, significantly decreased the TBARS levels and T-SH contents in all tissues in addition to NP-SH content in kidney, liver, lung and brain compared to nicotine group. Nicotine treatment caused excessive production of free radicals and evoked the antioxidant molecules. However, inhibition of cyclooxygenase-2 selectively prevented the nicotine-induced oxidative tissue damage dramatically. We concluded that, cyclooxygenase-2 pathway may be a notable mechanism of the nicotine toxicity.en_US
dc.identifier.doi10.1501/eczfak_0000000552
dc.identifier.endpage42en_US
dc.identifier.issn1015-3918
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84888124270en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.1501/eczfak_0000000552
dc.identifier.urihttps://hdl.handle.net/11616/90805
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectCyclooxygenase-2en_US
dc.subjectLipid peroxidationen_US
dc.subjectNicotine toxicityen_US
dc.subjectOxidative stressen_US
dc.titleEffect of cyclooxygenase-2 inhibition on nicotine-induced oxidative stressen_US
dc.typeArticleen_US

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