Effects of acrylamide and crocin on rat lung tissue

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dc.contributor.authorErdemli, Zeynep
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorBağ, Harika Gözükara
dc.contributor.authorAltınöz, Eyüp
dc.date.accessioned2024-08-04T19:42:40Z
dc.date.available2024-08-04T19:42:40Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: We aimed to determine the effects of acrylamide (AA) and crocin (Cr) on rat lung tissues. Materials and Methods: Forty Wistar albino rats were divided into control, AA, Cr, and AA + Cr groups. Rats were administered 25 mg/kg AA and 50 mg/kg Cr for 21 days. After 21 days, malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT) and protein levels were measured in rat lung tissues. Results: The analysis of the rat lung tissues revealed that oxidant parameter markers (MDA, TOS, OSI) increased and antioxidant parameter markers (GSH, TAS, SOD, CAT) decreased in the AA group when compared to all other groups (p < 0.05). A significant increase was determined in antioxidant capacity (GSH, TAS, SOD, CAT) in the Cr-treatment group when compared to all other groups (p < 0.05). We found a significant improvement in oxidant-antioxidant parameters in the AA + Cr group when compared to the AA group (p < 0.05). Conclusion: This study was the first of its kind in the literature and revealed that AA administration led to damages in lung tissue. It could be suggested that this was due to an increase in oxidant levels and oxidative stress. Cr exerted a powerful antioxidant effect in lung tissues. Against AA toxicity, we recommend the consumption of Cr to improve antioxidant capacity.en_US
dc.identifier.doi10.5455/annalsmedres.2021.06.477
dc.identifier.endpage400en_US
dc.identifier.issn2636-7688
dc.identifier.issue4en_US
dc.identifier.startpage397en_US
dc.identifier.trdizinid518022en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2021.06.477
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/518022
dc.identifier.urihttps://hdl.handle.net/11616/88563
dc.identifier.volume29en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of acrylamide and crocin on rat lung tissueen_US
dc.typeArticleen_US

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