Vitamin-D Insufficiency Leads to Interleukin-10 Reduction in Peri-Implant Tissues: A Case-Control Study

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dc.contributor.authorToy, Vesile Elif
dc.contributor.authorSabanci, Arife
dc.contributor.authorDundar, Muhammed
dc.contributor.authorDisli, Faruk
dc.contributor.authorYildiz, Sedat
dc.contributor.authorAral, Kubra
dc.date.accessioned2026-04-04T13:33:22Z
dc.date.available2026-04-04T13:33:22Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectives Vitamin D has been reported to be crucial for bone mineralization and to play a significant role in immune and inflammatory responses. Its deficiency has been stated to be highly prevalent and might alter osseointegration of dental implants. Successful osseointegration has been claimed to be a critical aspect of implant survival and the effects of vitamin D on implant osseointegration have not been well documented. This study aimed to evaluate bone markers and cytokine levels of patients with or without vitamin D insufficiency. Material and Methods A total of 42 patients were included and divided into two groups: vitamin D insufficient (Group IN-S; n = 21) and vitamin D sufficient (Group S; n = 21). Besides clinical periodontal parameters and implant stability measurements, the levels of RANKL, OPG, osteocalcin (OC), calcium (Ca), tumor necrosis factor alpha (TNF-alpha), IL-1 beta, caspase-1 (CASP1), and IL-10 in bone biopsy from implant preparation sockets and peri-implant crevicular fluid (PICF) were determined by enzyme-linked immunosorbent assay (ELISA). The results were represented as concentration and total amount. Results PICF RANKL levels (both concentration and total amount) were higher in patients with Vitamin D insufficiency compared to sufficient controls (p < 0.05). Concentration and total amount of IL-10 were significantly lower in vitamin D insufficient participants than those of vitamin D sufficient group (p < 0.05). No differences were detected between the groups in terms of other parameters. Bone levels of all evaluated parameters also did not differ between the groups (p > 0.05). Conclusion It may be concluded that a low serum level of vitamin D may affect peri-implant health through altering IL-10 and RANKL.
dc.description.sponsorshipInonu University Research Fund [TSA-2022-2992]
dc.description.sponsorshipThis study was supported by Inonu University Research Fund Grant TSA-2022-2992.
dc.identifier.doi10.1111/cid.13425
dc.identifier.issn1523-0899
dc.identifier.issn1708-8208
dc.identifier.issue1
dc.identifier.orcid0000-0001-5183-6295
dc.identifier.orcid0000-0001-6509-2012
dc.identifier.pmid39930521
dc.identifier.scopus2-s2.0-85218430114
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/cid.13425
dc.identifier.urihttps://hdl.handle.net/11616/109109
dc.identifier.volume27
dc.identifier.wosWOS:001417695000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Implant Dentistry and Related Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectcalcium
dc.subjectIL-10
dc.subjectosteointegration
dc.subjectperi-implantitis
dc.subjectRANKL
dc.subjectvitamin D
dc.titleVitamin-D Insufficiency Leads to Interleukin-10 Reduction in Peri-Implant Tissues: A Case-Control Study
dc.typeArticle

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