Antioxidant effects of midazolam, isoflurane and desflurane during coronary artery by-pass grafting surgery

Basit Öğe Kaydı
dc.authorscopusid7006384185
dc.authorscopusid55942251200
dc.authorscopusid55666804700
dc.authorscopusid7003586739
dc.authorscopusid6603836580
dc.authorscopusid7004486274
dc.contributor.authorÖztürk E.
dc.contributor.authorBut A.
dc.contributor.authorToprak H.I.
dc.contributor.authorDemirbilek S.
dc.contributor.authorGüleç M.
dc.contributor.authorErsoy M.Ö.
dc.date.accessioned2024-08-04T20:02:12Z
dc.date.available2024-08-04T20:02:12Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt has been suggested that the reactive oxygen species (ROS) have essential role in the pathogenesis of myocardial ischemia-reperfusion injury. ROS may cause cardiac problems such as myocardial stunning, tissue damage and reperfusion cardiac arrhythmias may occur during weaning from pump in coronary artery bypass grafting (CABG). The aim of this study was compare the effects of midazolam, isoflurane, and desflurarie on the oxidative stress and hemodynamic parameters during CABG. After standard anesthesia induction, ninety patients were randomly allocated to Group M (midazolam), Group 1 (isoflurane), Group D (desflurane). Blood samples were obtained from the retrograde cannula placed in the coronary sinus; just prior to connecting to the pump (T1) and 5 minute after the cross-clamp removal (T2). In group M, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and adenosine deaminase (ADA) significantly increased, and nitric oxide (NO) and malondialdehyde (MDA) decreased at the T2 compared to the T1 (p<0.05). In Group 1, SOD and ADA increased at the T2 compared to the T1. While NO and MDA decreased, ADA increased in Group D at the T2 in comparison with the T1 (p<0.05). GSH-Px was significantly higher in Group M than Group 1 and D at the T2 (p<0.05). Although ADA was lower at the T2 in Group M than Group 1 and D, but there was only statistically significant difference between Group M and D (p<0.05). Midazolam had greater stimulating capacity on the endogenous antioxidant system and may caused less cellular damage than isoflurane and desjlurane due to its effects on the ADA.en_US
dc.identifier.endpage122en_US
dc.identifier.issn1305-5550
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-76349084488en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://hdl.handle.net/11616/91501
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofGogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary surgeryen_US
dc.subjectDesfluraneen_US
dc.subjectIsofluraneen_US
dc.subjectMidazolamen_US
dc.subjectOxidative stressen_US
dc.titleAntioxidant effects of midazolam, isoflurane and desflurane during coronary artery by-pass grafting surgeryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu