Effects of gallic acid and quercetin on the structural, thermal, spectroscopic, in vitro biocompatibility and electronic properties of Au-based hydroxyapatite structure

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dc.contributor.authorKeser, Serhat
dc.contributor.authorDogan, Ahmet
dc.contributor.authorAtes, Tankut
dc.contributor.authorBarzinjy, Azeez A.
dc.contributor.authorAtes, Burhan
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2026-04-04T13:34:56Z
dc.date.available2026-04-04T13:34:56Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractThe aim of this study is investigating the structural, thermal, spectroscopic, electronic and biocompatibility properties of the Au-based hydroxyapatites containing quercetin (Q) or gallic acid (GA) at various concentration. Different characterization techniques including; XRD analysis, FTIR and Raman spectroscopies, differential thermal analysis, SEM and EDX analysis were utilized. Cell cytotoxicity test was conducted with the cells of MG63 human bone cancer, hFOB 1.19 human osteoblast and Caco-2 human colon cancer. It has been shown that the utilized samples had no cytotoxic activity on the L-929, hFOB 1.19 and MG-63 cells. However, these samples had cytotoxic activity on Caco-2. The current study showed that the bandgap of the un-doped HAp structure was 4.976 eV. The crystallite size is also affected by Au-doping, type of the as-used biological additive and its amount. Also, the as-produced samples were thermally stable in the range from room temperature to 1000 degrees C. The particle size distributions of the samples were found at variable ranges. The molar ratios were close to the stoichiometric value of 1.667. These novel findings not only expand our appreciation for the role of dopants in materials science but also opens avenues for deliberate engineering of electronic properties for enhanced performance in various applications.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [222Z220]; TUBITAK; Management Unit of Scientific Research Projects of Firat University (FUBAP) [MMY.24.01, MMY.24.02]
dc.description.sponsorshipThis study was supported by Scientific and Technological Research Council of Turkey (TUBITAK) under the Grant Number 222Z220. The authors thank to TUBITAK for their supports. This work was also supported by the Management Unit of Scientific Research Projects of Firat University (FUBAP) (Project Numbers: MMY.24.01 and MMY.24.02).
dc.identifier.doi10.1016/j.matchemphys.2024.129892
dc.identifier.issn0254-0584
dc.identifier.issn1879-3312
dc.identifier.orcid0000-0002-4519-2953
dc.identifier.orcid0000-0003-4009-9845
dc.identifier.orcid0000-0002-9678-1053
dc.identifier.orcid0000-0002-2321-1455
dc.identifier.orcid0000-0001-6273-1309
dc.identifier.scopus2-s2.0-85201906995
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2024.129892
dc.identifier.urihttps://hdl.handle.net/11616/109501
dc.identifier.volume327
dc.identifier.wosWOS:001301820700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofMaterials Chemistry and Physics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectHydroxyapatite
dc.subjectGold (Au)
dc.subjectQuercetin
dc.subjectGallic acid
dc.subjectBandgap
dc.subjectX-ray diffraction (XRD)
dc.titleEffects of gallic acid and quercetin on the structural, thermal, spectroscopic, in vitro biocompatibility and electronic properties of Au-based hydroxyapatite structure
dc.typeArticle

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