An antibody of TNF-alpha did not prevent thioacetamide-induced hepatotoxicity in rats

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dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.contributor.authorDemirel, Ulvi
dc.contributor.authorHarputluoglu, Murat M. M.
dc.contributor.authorSeckin, Yuksel
dc.contributor.authorCiralik, Harun
dc.contributor.authorTemel, Ismail
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorOtlu, Baris
dc.date.accessioned2024-08-04T20:32:52Z
dc.date.available2024-08-04T20:32:52Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTumor necrosis factor (TNF)-alpha antibodies have been shown to reduce liver damage in different models. We investigated the effects of infliximab (a TNF-alpha antibody) on liver damage in thioacetamide (TAA)-induced hepatotoxicity in rats. Group 1 (n = 8) was the control group. In group 2 (n = 8), the TAA group, the rats received 300 mg/kg intraperitoneal (ip) TAA daily for 2 days. In group 3 (n = 8), the TAA + Infliximab (INF) group, infliximab (5 mg/kg ip daily) was administered 48 hours before the first dose of TAA daily for 2 days and was maintained for 4 consecutive days. In group 4 (n = 8), the INF group, the rats received only ip infliximab (5 mg/kg) daily. Livers were excised for histopathological and biochemical tests (thiobarbituric-acid-reactive substances [TBARS], and myeloperoxidase [MPO]). Serum ammonia, aspartate transaminase (AST), alanine transaminase (ALT), TNF-alpha, liver TBARS and MPO levels, and liver necrosis and inflammation scores in the TAA group were significantly higher than in the control and INF groups (all p < 0.01). All parameters except AST were not significantly different between TAA and TAA + INF. In conclusion, our results suggest that oxidative stress plays an important role in TAA-induced hepatotoxicity, and infliximab does not improve oxidative liver damage.en_US
dc.description.sponsorshipInonu University Bilimsel Arastirma Projeleri Birimi [2007/57]en_US
dc.description.sponsorshipThis work was supported by Inonu University Bilimsel Arastirma Projeleri Birimi (Scientific Research Projects Unit), funding number: 2007/57.en_US
dc.identifier.doi10.1177/0960327110374206
dc.identifier.endpage566en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue7en_US
dc.identifier.pmid20534638en_US
dc.identifier.scopus2-s2.0-79959728232en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage560en_US
dc.identifier.urihttps://doi.org/10.1177/0960327110374206
dc.identifier.urihttps://hdl.handle.net/11616/95365
dc.identifier.volume30en_US
dc.identifier.wosWOS:000291891200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectinfliximaben_US
dc.subjecttumor necrosis factor-alphaen_US
dc.subjectthioacetamideen_US
dc.subjectoxidative stressen_US
dc.subjectliveren_US
dc.titleAn antibody of TNF-alpha did not prevent thioacetamide-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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