Potent therapeutic effect of melatonin on aging skin in pinealectomized rats

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dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorEsrefoglu, M
dc.contributor.authorSeyhan, M
dc.contributor.authorGül, M
dc.contributor.authorParlakpinar, H
dc.contributor.authorBatçioglu, K
dc.contributor.authorUyumlu, B
dc.date.accessioned2024-08-04T20:15:01Z
dc.date.available2024-08-04T20:15:01Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt is generally agreed that one of the major contributors to skin aging is reactive oxygen species. As organisms reach advanced age, free radical generation increases and the activity of tissue antioxidant enzyme system decreases. Melatonin is an antioxidant and free radical scavenger. The present study was first aimed to determine the morphometric and biochemical changes caused by long-term pinealectomy in order to investigate the role of melatonin as skin architecture. Secondly, the effect of exogenous melatonin administration on these changes was determined. Rats were pinealectomized or sham operated (control) for 6 months. Half of the pinealectomized rats were treated with 4 mg/kg melatonin during the last month of the experiment. Pinealectomy resulted in important morphometric and biochemical changes in the back, abdominal and thoracic skin. The thickness of epidermis and dermis and the number of dermal papillae and hair follicles were reduced. Melatonin administration to pinealectomized rats significantly improved these alterations in all body areas (P < 0.005). On the contrary, in pinealectomized rats the levels of antioxidant enzymes, catalase and glutathione peroxidase were decreased. Melatonin restored the levels of these enzymes. The pinealectomy-induced increases in lipid peroxidation in the abdominal and thoracic skin were significantly reduced by melatonin treatment (P < 0.005 and 0.01 respectively). These results suggest that melatonin is highly efficient anti-aging factor and, as melatonin levels decrease with age, melatonin treatment may reduce age-related skin changes.en_US
dc.identifier.doi10.1111/j.1600-079X.2005.00235.x
dc.identifier.endpage237en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue3en_US
dc.identifier.pmid16150102en_US
dc.identifier.scopus2-s2.0-25144502329en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2005.00235.x
dc.identifier.urihttps://hdl.handle.net/11616/94098
dc.identifier.volume39en_US
dc.identifier.wosWOS:000231621600003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectagingen_US
dc.subjectantioxidant systemen_US
dc.subjectmelatoninen_US
dc.subjectskinen_US
dc.subjectthicknessen_US
dc.titlePotent therapeutic effect of melatonin on aging skin in pinealectomized ratsen_US
dc.typeArticleen_US

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