Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study

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dc.authoridGedikbasi, Asuman/0000-0001-7121-6077
dc.authoridJankauskiene, Augustina/0000-0001-7767-2102
dc.authoridMontini, Giovanni/0000-0002-7350-4475
dc.authoridDuzova, Ali/0000-0002-4365-2995
dc.authoridTurkkan, Ozde Nisa/0000-0003-2928-9031
dc.authoridDurmu, Mehmet Akif/0000-0002-3637-6451
dc.authoridTaşdemir, Mehmet/0000-0002-5579-6339
dc.authorwosidYuruk Yildirim, Zeynep Nagehan/AAE-1511-2020
dc.authorwosidGedikbasi, Asuman/AAE-3613-2020
dc.authorwosidJankauskiene, Augustina/AFQ-3737-2022
dc.authorwosidMontini, Giovanni/AAC-6612-2022
dc.authorwosidDuzova, Ali/AAB-7692-2021
dc.authorwosidTurkkan, Ozde Nisa/HGV-0948-2022
dc.authorwosidDurmu, Mehmet Akif/JWO-3385-2024
dc.contributor.authorAksu, Bagdagul
dc.contributor.authorAfonso, Alberto Caldas
dc.contributor.authorAkil, Ipek
dc.contributor.authorAlpay, Harika
dc.contributor.authorAtmis, Bahriye
dc.contributor.authorAydog, Ozlem
dc.contributor.authorBayazit, Aysun Karabay
dc.date.accessioned2024-08-04T20:54:31Z
dc.date.available2024-08-04T20:54:31Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground One of the most common bacterial infections in childhood is urinary tract infection (UTI). Toll-like receptors (TLRs) contribute to immune response against UTI recognizing specific pathogenic agents. Our aim was to determine whether soluble TLR4 (sTLR4), soluble TLR5 (sTLR5) and interleukin 8 (IL-8) can be used as biomarkers to diagnose UTI. We also aimed to reveal the relationship between urine Heat Shock Protein 70 (uHSP70) and those biomarkers investigated in this study.Methods A total of 802 children from 37 centers participated in the study. The participants (n = 282) who did not meet the inclusion criteria were excluded from the study. The remaining 520 children, including 191 patients with UTI, 178 patients with non-UTI infections, 50 children with contaminated urine samples, 26 participants with asymptomatic bacteriuria and 75 healthy controls were included in the study. Urine and serum levels of sTLR4, sTLR5 and IL-8 were measured at presentation in all patients and after antibiotic treatment in patients with UTI.Results Urine sTLR4 was higher in the UTI group than in the other groups. UTI may be predicted using 1.28 ng/mL as cut-off for urine sTLR4 with 68% sensitivity and 65% specificity (AUC = 0.682). In the UTI group, urine sTLR4 levels were significantly higher in pyelonephritis than in cystitis (p < 0.0001). Post-treatment urine sTLR4 levels in the UTI group were significantly lower than pre-treatment values (p < 0.0001).Conclusions Urine sTLR4 may be used as a useful biomarker in predicting UTI and subsequent pyelonephritis in children with UTI.en_US
dc.description.sponsorshipESPN (European Society for Pediatric Nephrology); Istanbul University Scientific Research Project Foundation; Istanbul Faculty of Medicine Foundation; Children's Kidney Health Societyen_US
dc.description.sponsorshipThe UTILISE study was supported by ESPN (European Society for Pediatric Nephrology), Istanbul University Scientific Research Project Foundation, Istanbul Faculty of Medicine Foundation, and by the Children's Kidney Health Society. We thank all these institutions/organizations for their support. In addition, we are also grateful to our students Isil Gul, Sevgi Ipar, Zeynep Sakur, and our chemist Orhan Tepeli, who worked actively in this study, for their help and assistance.en_US
dc.identifier.doi10.1007/s00467-023-06063-0
dc.identifier.endpage491en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue2en_US
dc.identifier.pmid37462743en_US
dc.identifier.scopus2-s2.0-85165011036en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage483en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-023-06063-0
dc.identifier.urihttps://hdl.handle.net/11616/101470
dc.identifier.volume39en_US
dc.identifier.wosWOS:001032860200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectToll-like receptor 4en_US
dc.subjectTLR4en_US
dc.subjectUrinary tract infectionen_US
dc.subjectUTIen_US
dc.subjectUTILISE studyen_US
dc.titleUrine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Studyen_US
dc.typeArticleen_US

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