Cytotoxic effects of cucurbitacin i and ecballium elaterium on breast cancer cells

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dc.authorscopusid57202358220
dc.authorscopusid57201195704
dc.authorscopusid8222278800
dc.authorscopusid56168381700
dc.authorscopusid7004914053
dc.authorscopusid26024440900
dc.contributor.authorYilmaz K.
dc.contributor.authorKarakuş F.
dc.contributor.authorEyol E.
dc.contributor.authorTosun E.
dc.contributor.authorYilmaz I.
dc.contributor.authorÜnüvar S.
dc.date.accessioned2024-08-04T20:03:29Z
dc.date.available2024-08-04T20:03:29Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study was to investigate the inhibitory effect of cucurbitacin I (CuI) and Ecballium elaterium L. (fruit juice and chloroform extract) on breast cancer cells (MCF-7 and MDA-MB-231). The CuI content of E. elaterium fruit juice and chloroform extract was quantified using high performance liquid chromatography. The cytotoxic effects of the fruit juice, chloroform extract and CuI were determined by MTT, wound healing and colony formation assays; all had an anti-proliferative activity on the breast cancer cells. Clarifying the mechanisms of cucurbitacins will enable the identification of new molecular targets for breast cancer therapy. © 2018 Natural Product Incorporation.en_US
dc.identifier.endpage1448en_US
dc.identifier.issn1934-578X
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85057862390en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1445en_US
dc.identifier.urihttps://hdl.handle.net/11616/91842
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNatural Product Incorporationen_US
dc.relation.ispartofNatural Product Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectCucurbitacin Ien_US
dc.subjectEcballium elateriumen_US
dc.subjectMCF-7en_US
dc.subjectMDA-MB-231en_US
dc.titleCytotoxic effects of cucurbitacin i and ecballium elaterium on breast cancer cellsen_US
dc.typeArticleen_US

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