Combined (dual) drug therapy for the treatment of patent ductus arteriosus: last approach prior to ligation

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dc.authoridÖncül, Mehmet/0000-0001-5874-7826
dc.authoridDeveci, Mehmet Fatih/0000-0002-3328-4156
dc.authoridKarakurt, Cemsit/0000-0002-9246-8107
dc.authoridyurttutan, Sadik/0000-0002-4994-9124
dc.authorwosidÖncül, Mehmet/ABV-4995-2022
dc.authorwosidKaya, Hüseyin/AAW-6805-2021
dc.authorwosidDeveci, Mehmet Fatih/IYS-3534-2023
dc.contributor.authorDeveci, Mehmet F.
dc.contributor.authorKaya, Huseyin
dc.contributor.authorYurttutan, Sadik
dc.contributor.authorAlagoz, Meral
dc.contributor.authorGokce, Ismail K.
dc.contributor.authorKarakurt, Cemsit
dc.contributor.authorGullu, Ufuk U.
dc.date.accessioned2024-08-04T20:54:39Z
dc.date.available2024-08-04T20:54:39Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: We aimed to evaluate the efficacy of combined (ibuprofen+paracetamol) medical therapy in cases of persistent haemodynamically significant patent ductus arteriosus that are resistant to standard medical monotherapy (ibuprofen and/or paracetamol) in this retrospective multi-centre study. Methods: The combined therapy included the administration of 15mg/kg/dose of paracetamol every 6 h for 3 days and ibuprofen at an initial dose of 10mg/kg/dose followed by 5 mg/kg/dose every 24 h. After 2 days following the administration of the last dose, the researchers evaluated the efficacy of combined treatment by conducting an echocardiographic examination. Results: Of all 42 patients who received combined therapy, 37 (88.1%) patients exhibited closure of the haemodynamically significant patent ductus arteriosus without requiring surgical ligation. Patients who did not respond to combined therapy had a higher mean birth weight and gestational age compared to those who responded (p < 0.05). Conclusion: The researchers believe the success of ibuprofen and paracetamol in haemodynamically significant patent ductus arteriosus treatment may be due to their synergistic efficacy and inhibition of the prostaglandin synthesis pathway through different enzymes. The results of our retrospective trial suggest that combination therapy with paracetamol and ibuprofen can be attempted when monotherapy is unsuccessful in treating haemodynamically significant patent ductus arteriosus, especially in centres without a surgical department.en_US
dc.identifier.doi10.1017/S1047951122003699
dc.identifier.endpage1315en_US
dc.identifier.issn1047-9511
dc.identifier.issn1467-1107
dc.identifier.issue8en_US
dc.identifier.pmid36472120en_US
dc.identifier.scopus2-s2.0-85169710042en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1312en_US
dc.identifier.urihttps://doi.org/10.1017/S1047951122003699
dc.identifier.urihttps://hdl.handle.net/11616/101556
dc.identifier.volume33en_US
dc.identifier.wosWOS:001067468300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCardiology in The Youngen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPatent ductus arteriosusen_US
dc.subjectCombined therapyen_US
dc.subjectDual medication therapyen_US
dc.subjectParacetamolen_US
dc.subjectIbuprofenen_US
dc.titleCombined (dual) drug therapy for the treatment of patent ductus arteriosus: last approach prior to ligationen_US
dc.typeArticleen_US

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