Assessment of Liver Fibrosis with Diffusion-Weighted Magnetic Resonance Imaging Using Different b-values in Chronic Viral Hepatitis

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dc.authoridGÜL, YELİZ/0000-0001-9280-3254
dc.authoridDagli, Adile Ferda/0000-0003-4077-4134;
dc.authorwosidGÜL, YELİZ/KCK-7383-2024
dc.authorwosidDagli, Adile Ferda/W-7878-2018
dc.authorwosidPoyrazoglu, Orhan Kursat/W-7898-2018
dc.contributor.authorKocakoc, Ercan
dc.contributor.authorBakan, Ayse Ahsen
dc.contributor.authorPoyrazoglu, Orhan Kursat
dc.contributor.authorDagli, Adile Ferda
dc.contributor.authorGul, Yeliz
dc.contributor.authorCicekci, Mehtap
dc.contributor.authorBahcecioglu, Ibrahim Halil
dc.date.accessioned2024-08-04T20:41:18Z
dc.date.available2024-08-04T20:41:18Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To examine the effectiveness of apparent diffusion coefficient (ADC) values and to compare the reliability of different b-values in detecting and identifying significant liver fibrosis. Subjects and Methods: There were 44 patients with chronic viral hepatitis (CVH) in the study group and 30 healthy participants in the control group. Diffusion-weighted magnetic resonance imaging (DWI) was performed before the liver biopsy in patients with CVH. The values of ADC were measured with 3 different b-values (100, 600, 1,000 s/mm(2)). In addition, liver fibrosis was classified using the modified Ishak scoring system. Liver fibrosis stages and ADC values were compared using areas under the receiver-operating characteristic (ROC) curve. Results: The study group's mean ADC value was not statistically significantly different from the control group's mean ADC value at b = 100 s/mm(2) (3.69 +/- 0.5 x 10(-3) vs. 3.7 +/- 0.3 x 10(-3) mm(2)/s) and b = 600 s/mm(2) (2.40 +/- 0.3 x 10(-3) vs. 2.5 +/- 0.5 x 10(-3) mm(2)/s). However, the study group's mean ADC value (0.99 +/- 0.3 x 10(-3) mm(2)/s) was significantly lower than that of the control group (1.2 +/- 0.1 x 10(-3) mm(2)/s) at b = 1,000 s/mm(2). With b = 1,000 s/mm(2) and the cutoff ADC value of 0.0011 mm(2)/s for the diagnosis of liver fibrosis, the mean area under the ROC curve was 0.702 +/- 0.07 (p = 0.0015). For b = 1,000 s/mm(2) and the cutoff ADC value of 0.0011 mm(2)/s to diagnose significant liver fibrosis (Ishak score = 3), the mean area under the ROC curve was 0.759 +/- 0.07 (p = 0.0001). Conclusion: Measurement of ADC values by DWI was effective in detecting liver fibrosis and accurately identifying significant liver fibrosis when a b-value of 1,000 s/mm(2) was used. (C) 2015 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000434682
dc.identifier.endpage526en_US
dc.identifier.issn1011-7571
dc.identifier.issn1423-0151
dc.identifier.issue6en_US
dc.identifier.pmid26183515en_US
dc.identifier.scopus2-s2.0-84946498694en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage522en_US
dc.identifier.urihttps://doi.org/10.1159/000434682
dc.identifier.urihttps://hdl.handle.net/11616/97041
dc.identifier.volume24en_US
dc.identifier.wosWOS:000364216200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofMedical Principles and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitisen_US
dc.subjectFibrosisen_US
dc.subjectLiveren_US
dc.subjectDiffusion-weighted imagingen_US
dc.titleAssessment of Liver Fibrosis with Diffusion-Weighted Magnetic Resonance Imaging Using Different b-values in Chronic Viral Hepatitisen_US
dc.typeArticleen_US

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