Synthesis, characterization and antimicrobial properties of silver complexes derived from 5,6-Dimethylbenzimidazol-2-ylidene

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dc.authoridCetinkaya, Erdem/0000-0001-6911-5795
dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authorwosidCetinkaya, Erdem/AAD-1656-2019
dc.authorwosidÜstün, Elvan/HJB-1157-2022
dc.contributor.authorCetinkaya, Erdem Atalay
dc.contributor.authorKoc, Ahmet
dc.contributor.authorKoc, Hatice Kubra
dc.contributor.authorKarabiyik, Hande
dc.contributor.authorKarabiyik, Hasan
dc.contributor.authorUstun, Elvan
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:53:34Z
dc.date.available2024-08-04T20:53:34Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBenzimidazoles are considered as a class of bioactive heterocyclic compounds that exhibit many biological ac-tivities such as antimicrobial. Benzimidazole-silver complexes also have strong antimicrobial activity, sometimes even higher than that of conventionally used silver antimicrobials. In this study, six new 5,6-dimethylbenzimi-dazolium ligand precursors which were functionalized by using 2-naphthylmethyl and their silver complexes were synthesized. All molecules were characterized by elemental analysis, 1H NMR, 13C NMR, and IR spec-troscopy techniques. Additionally, mu-Dichloro-bis{[1-(2-naphthylmethyl)-3-(benzyl)-5,6-dimethylbenzimidazol-2-ylidene]silver(I)} was characterized structurally in the solid state by X-ray crystallography which was found to be dimeric with two bridging chlorides. In vitro antimicrobial activity of the synthesized compounds investigated in this work was tested against the reference strains: Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC MYA-2876) and Candida glabrata (ATCC 2001). Some of these new compounds have been found to display significant effectiveness. Also, the molecular docking analysis was performed for all optimized ligands and complexes against SarAen_US
dc.description.sponsorshipTechnological and Scientific Research Council of Turkiye (TBITAK) [121Z158]en_US
dc.description.sponsorshipThe Technological and Scientific Research Council of Turkiye (TBITAK) provided funding for this work (Project No: 121Z158) .en_US
dc.identifier.doi10.1016/j.poly.2023.116383
dc.identifier.issn0277-5387
dc.identifier.issn1873-3719
dc.identifier.scopus2-s2.0-85151364360en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2023.116383
dc.identifier.urihttps://hdl.handle.net/11616/101265
dc.identifier.volume237en_US
dc.identifier.wosWOS:000969691700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectSilver complexesen_US
dc.subjectAntimicrobial activityen_US
dc.subject5en_US
dc.subject6-dimethylbenzimidazoleen_US
dc.subjectMolecular dockingen_US
dc.titleSynthesis, characterization and antimicrobial properties of silver complexes derived from 5,6-Dimethylbenzimidazol-2-ylideneen_US
dc.typeArticleen_US

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