Effect of aminoguanidine on ischemia-reperfusion induced myocardial injury in rats

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dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorParlakpinar, H
dc.contributor.authorOzer, MK
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:14:57Z
dc.date.available2024-08-04T20:14:57Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMyocardial ischemia-reperfusion (MI/R) has been implicated in the induction of inducible nitric oxide synthase (iNOS) that leads to increase production of nitric oxide (NO). Recently, excessive production of NO has been involved in causing myocardial injury. In our in vivo model, we examined the effects of aminoguanidine (AMG), a known iNOS inhibitor, on percentage infarct size in anaesthetized rats. A total of 14 rats were equally divided into two groups (n = 7 in each group). To produce myocardial necrosis, the left main coronary artery was occluded for 30 min, followed by 120 min of reperfusion, in anesthetized rats. AMG (200 mg kg(-1)) was given intravenously 10 min before occlusion. The volume of infarct size and the risk zone were determined by planimentry of each tracing and multiplying by the slice thickness. Infarct size was normalized by expressing it as a percentage of the area at risk. Hemodynamic parameters were measured via the left carotid artery. Compared to MI/R group, whereas AMG administration elevated mean arterial blood pressure, statistically reduced the myocardial infarct size (21 +/- 1 and 14 +/- 4%, respectively) and infract size/risk zone (53 +/- 3 and 37 +/- 5%, respectively) in rat model of ischemia-reperfusion. In conclusion, this study indicates that iNOS inhibitor, AMG, show reduction in NO's side effect in I/R injury.en_US
dc.identifier.doi10.1007/s11010-005-5779-9
dc.identifier.endpage142en_US
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue1-2en_US
dc.identifier.pmid16132725en_US
dc.identifier.scopus2-s2.0-24144461924en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-005-5779-9
dc.identifier.urihttps://hdl.handle.net/11616/94078
dc.identifier.volume277en_US
dc.identifier.wosWOS:000231220600018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaminoguanidine (AMG)en_US
dc.subjectinfarct sizeen_US
dc.subjectischemia-reperfusionen_US
dc.subjectmyocardial injury heart and raten_US
dc.titleEffect of aminoguanidine on ischemia-reperfusion induced myocardial injury in ratsen_US
dc.typeArticleen_US

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