Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridKose, Evren/0000-0002-0246-2589
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridSarihan, Mehmet Ediz/0000-0002-1266-4213
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidKose, Evren/ABG-9908-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidSarıhan, Mehmet Ediz/JMQ-5971-2023
dc.contributor.authorKose, Evren
dc.contributor.authorOguz, Fatih
dc.contributor.authorVardi, Nigar
dc.contributor.authorSarihan, Mehmet Ediz
dc.contributor.authorBeytur, Ali
dc.contributor.authorYucel, Aytac
dc.contributor.authorPolat, Alaadin
dc.date.accessioned2024-08-04T20:45:56Z
dc.date.available2024-08-04T20:45:56Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats. Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: Control; Group II: Control+ML; Group III: DOX; Group IV: DOX+ML; Group V: ML+DOX. At the end of the experiment, the kidney tissues of rats were collected. Thiobarbituric acid reactive substance (TBARS), reduced glutathione, superoxide dismutase (SOD), and catalase levels were determined from the kidney tissues. In addition, the kidney tissues were examined histologically. Results: DOX induced a significant increase in the kidney TBARS levels, whereas SOD contents significantly decreased when compared with the control group. On the other hand, ML administration before and after DOX injection caused significant decreases in TBARS production and also increases in SOD levels. Histologically, the most remarkable damage was glomerulosclerosis and tubular changes in the DOX group. Moreover, marked tubular necrosis and swelling in tubular epithelial cells were observed in this group. Contrarily, although glomerulosclerosis was recognized as alleviated also in both DOX+ML and ML+DOX groups, the lesions did not completely ameliorate. However, treatment with ML after DOX injection was more effective than treatment with ML before DOX injection with respect to the protection of tubular structures. Conclusion: It was determined that ML treatment after DOX injection caused therapeutic effects against DOX-induced kidney damage. Thence, ML treatment is of some clinical properties for oxidative stress damage in kidney tissues.en_US
dc.identifier.doi10.22038/ijbms.2019.33493.7996
dc.identifier.endpage411en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue4en_US
dc.identifier.pmid31168345en_US
dc.identifier.scopus2-s2.0-85065546082en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage407en_US
dc.identifier.urihttps://doi.org/10.22038/ijbms.2019.33493.7996
dc.identifier.urihttps://hdl.handle.net/11616/98790
dc.identifier.volume22en_US
dc.identifier.wosWOS:000459559700010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectHistologyen_US
dc.subjectKidneyen_US
dc.subjectLeukotrienesen_US
dc.subjectOxidative stressen_US
dc.subjectTBARSen_US
dc.titleTherapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in ratsen_US
dc.typeArticleen_US

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