Penile alterations at early stage of type 1 diabetes in rats

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dc.authorwosidLiu, Guiming/AAM-2688-2020
dc.contributor.authorTao, Mingfang
dc.contributor.authorTasdemir, Cemal
dc.contributor.authorTasdemir, Seda
dc.contributor.authorShahabi, Ali
dc.contributor.authorLiu, Guiming
dc.date.accessioned2024-08-04T20:43:57Z
dc.date.available2024-08-04T20:43:57Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods: Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results: The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions: Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted.en_US
dc.description.sponsorshipNational Center for Research Resource (NIH-NCRR) [1S10RR031845]en_US
dc.description.sponsorshipWe thank C. Thomas Powell, PhD for his medical editorial assistance. We thank Patty Conrad for her assistance in analyzing the images. We would like to acknowledge the use of the Leica SCN400 Slide Scanner and the Visiopharm Image Analysis software in the Genetics Department Imaging Facility at CWRU, made available through a National Center for Research Resource (NIH-NCRR) Shared Instrumentation Grant (1S10RR031845).en_US
dc.identifier.doi10.1590/S1677-5538.IBJU.2016.0454
dc.identifier.endpage761en_US
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue4en_US
dc.identifier.pmid28338308en_US
dc.identifier.scopus2-s2.0-85027965123en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage753en_US
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2016.0454
dc.identifier.urihttps://hdl.handle.net/11616/97941
dc.identifier.volume43en_US
dc.identifier.wosWOS:000407352000024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBrazilian Soc Urolen_US
dc.relation.ispartofInternational Braz J Urolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectPenisen_US
dc.subjectErectile Dysfunctionen_US
dc.titlePenile alterations at early stage of type 1 diabetes in ratsen_US
dc.typeArticleen_US

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