Investigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats

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dc.contributor.authorCelikoz, Nihan
dc.contributor.authorYilmaztekin, Yakup
dc.contributor.authorCankaya, Ozlem
dc.contributor.authorTaslidere, Asli
dc.contributor.authorDatli, Rumeyza Hilal
dc.contributor.authorUyumlu, Ayse Burcin
dc.contributor.authorGenc, Metin Fikret
dc.date.accessioned2026-04-04T13:30:43Z
dc.date.available2026-04-04T13:30:43Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: In the present study, we aimed to investigate the protective effect of Hydrogen acute kidney injury induced by cisplatin in rats. Materials and Methods: Four groups of Wistar albino rats were formed with 10 rats in each group: Control group, Cisplatin group, Cisplatin+SA group, and Cisplatin+NaHS group. The activities of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) and Cystathione gamma-lyase (CSE), and the levels of Malondialdehyde (MDA), Glutathione (GSH) and total GSH were measured. Creatinine, urea, Alanine Aminotransferase (ALT) were also measured. Results: CAT activity increased in the cisplatin+SA and cisplatin+NaHS groups. CSE activity increased in the cisplatin+NaHS group. MDA levels increased in the cisplatin and cisplatin+NaHS groups. This increase was also observed in SOD and GPx activities but was not statistically significant. Serum ALT, AST, creatinine, and urea levels were higher in the cisplatin group. ADP activity was lower in the cisplatin group. The histological findings support the biochemical results obtained in our study. Red/total GSH was higher in the cisplatin, cisplatin+SA, and cisplatin+NaHS groups. Conclusion: SA and NaHS would have beneficial effects in preventing cisplatin-induced kidney damage.
dc.description.sponsorshipInonu University Scientific Research Projects Unit [TYL-2021/2561]
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Research Projects Unit (project number TYL-2021/2561) .
dc.identifier.doi10.5530/ijper.20261390
dc.identifier.endpage420
dc.identifier.issn0019-5464
dc.identifier.issue1
dc.identifier.orcid0000-0002-6244-0517
dc.identifier.scopus2-s2.0-105019303066
dc.identifier.scopusqualityQ3
dc.identifier.startpage410
dc.identifier.urihttps://doi.org/10.5530/ijper.20261390
dc.identifier.urihttps://hdl.handle.net/11616/108326
dc.identifier.volume60
dc.identifier.wosWOS:001620355800008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAssoc Pharmaceutical Teachers India
dc.relation.ispartofIndian Journal of Pharmaceutical Education and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectAcute kidney injury
dc.subjectHydrogen sulfide
dc.subjectSulfurized apricot
dc.subjectCisplatin.
dc.titleInvestigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats
dc.typeArticle

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