Risk factors for cervical stromal involvement in endometrioid-type endometrial cancer

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dc.authoridTOPRAK, SERHAT/0000-0003-4136-0523
dc.authoridTohma, Yusuf Aytaç/0000-0001-9418-4733
dc.authorwosidTOPRAK, Serhat/ABI-5367-2020
dc.authorwosidTOPRAK, SERHAT/AAD-7854-2021
dc.authorwosidTohma, Yusuf Aytaç/AAE-6482-2021
dc.contributor.authorToprak, Serhat
dc.contributor.authorSahin, Eda Adeviye
dc.contributor.authorSahin, Hanifi
dc.contributor.authorTohma, Yusuf Aytac
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorMeydanli, Mehmet Mutlu
dc.date.accessioned2024-08-04T20:49:13Z
dc.date.available2024-08-04T20:49:13Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectiveThe aim of this study was to identify predictors of cervical stromal involvement in women with endometrioid-type endometrial cancer (EEC). MethodsA total of 795 patients with EEC who underwent comprehensive surgical staging including pelvic and para-aortic lymph node dissection between January 2007 and December 2018 were retrospectively analyzed. Data including age, menopausal status, serum CA-125 levels, tumor size, lymphovascular space invasion (LVSI), depth of myometrial invasion, positive peritoneal cytology, cervical stromal involvement, histologic grade, recurrence, and follow-up duration were recorded. ResultsMedian follow up was 49 months. Cervical stromal invasion was found in 88 patients. Multivariate analysis revealed that presence of LVSI (hazard ratio [HR] 2, 95% confidence interval [CI] 1.02-4.25, P = 0.045), a primary tumor diameter of at least 3 cm (HR 3, 95% CI 1.31-7.25, P = 0.010), and at least 50% deep myometrial invasion (HR 2.7, 95% CI 1.37-5.41, P = 0.004) were independent risk factors for cervical stromal involvement in patients with EEC. ConclusionOur study results suggest that presence of LVSI, a primary tumor diameter of at least 3 cm, and LVSI of at least 50% seem to be independent predictors of cervical involvement in women with EEC. Tumor diameter of >= 3 cm, and lymphovascular space invasion >= 50% seem to be independent predictors of cervical involvement in patients with endometrioid-type endometrial cancer.en_US
dc.identifier.doi10.1002/ijgo.13449
dc.identifier.endpage55en_US
dc.identifier.issn0020-7292
dc.identifier.issn1879-3479
dc.identifier.issue1en_US
dc.identifier.pmid33118165en_US
dc.identifier.scopus2-s2.0-85099091497en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1002/ijgo.13449
dc.identifier.urihttps://hdl.handle.net/11616/99708
dc.identifier.volume153en_US
dc.identifier.wosWOS:000604897900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Gynecology & Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcervical stromal involvementen_US
dc.subjectendometrioid-type endometrial canceren_US
dc.subjectlymphovascular space invasionen_US
dc.titleRisk factors for cervical stromal involvement in endometrioid-type endometrial canceren_US
dc.typeArticleen_US

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