Extended-Spectrum ?-Lactamase-Producing Escherichia coli and Klebsiella spp. in Community-Acquired Urinary Tract Infections and Their Antimicrobial Resistance

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dc.authorwosidYAKUPOGULLARI, YUSUF/F-3966-2011
dc.contributor.authorSenol, Arzu
dc.contributor.authorYakupogullari, Yusuf
dc.contributor.authorSenol, Feray Ferda
dc.date.accessioned2024-08-04T20:48:54Z
dc.date.available2024-08-04T20:48:54Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Production of extended-spectrum beta-lactamases (ESBLs) is the most important antimicrobial resistance mechanism among Gram-negative pathogens. In this study, ESBL frequency and antimicrobial resistance of Escherichia coli and Klebsiella spp. isolated from community-acquired urinary tract infections (UTIs) are investigated. Methods: In this retrospective cross-sectional study, ESBL rates and the results of antimicrobial susceptibility tests were determined for E. coli and Klebsiella spp. grown in the urine cultures of 520 patients with community-acquired UTI, and the changes in the antimicrobial resistance rates of the isolates were compared in terms of ESBL production. Results: E. coli had grown in 220 samples and Klebsiella spp. in 38 samples. ESBL production frequencies of the isolates were found as 40% and 47.4%, respectively, and the rate of carbapenem resistance was found as 3.1%. Among the isolates, the highest resistance was found for amoxicillin-clavulanate (46%), ciprofloxacin (44.9%), and ceftriaxone (42.2%), while the lowest resistance was found for colistin (0.3%), fosfomycin (1.5%), amikacin (3.1%), and nitrofurantoin (4.2%). In ESBL-producers, significantly higher resistance was found for all antibiotics studied, except colistin, nitrofurantoin and fosfomycin. Conclusions: In this study, it was shown that almost half of the community-acquired isolates were ESBL-producers, and these isolates had acquired resistance against many antimicrobials including the last resorts such as carbapenems and colistin. To reduce the progress of resistance rates in E. coli and Klebsiella spp. which are the most common pathogens in community-acquired UTIs, their therapies should be planned according to the results of susceptibility tests as much as possible.en_US
dc.identifier.doi10.5152/kd.2020.34
dc.identifier.endpage168en_US
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85090528412en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.5152/kd.2020.34
dc.identifier.urihttps://hdl.handle.net/11616/99528
dc.identifier.volume33en_US
dc.identifier.wosWOS:000569378600011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherDoc Design Informatics Co Ltden_US
dc.relation.ispartofKlimik Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrinary tract infectionsen_US
dc.subjectextended-spectrum beta-lactamasesen_US
dc.subjectEscherichia colien_US
dc.subjectKlebsiella spp.en_US
dc.titleExtended-Spectrum ?-Lactamase-Producing Escherichia coli and Klebsiella spp. in Community-Acquired Urinary Tract Infections and Their Antimicrobial Resistanceen_US
dc.typeArticleen_US

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