The effectiveness of platelet-rich plasma in an anosmia-induced mice model
Yükleniyor...
Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wıley, 111 rıver st, hoboken 07030-5774, nj usa
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
ObjectiveIn this study, we aimed to functionally and morphologically demonstrate the effectiveness of platelet-rich plasma (PRP) on anosmia in a mouse model of anosmia.
Study DesignAnimal study.
MethodsA total of 16 male mice were included. When selecting the mice, the food-finding test (FFT) was used to make sure that the animals could smell, and anosmia was induced by administration of intraperitoneal 3-methylindole. The mice were randomly divided into two groups of eight (groups A and B). After 1 week, topical PRP was administered to the mice in group A and topical saline was administered to the mice in group B. The FFT was again administered at 7, 14, and 21 days. The mice were sacrificed on day 21, the olfactory neuroepithelium was histopathologically examined, and the epithelial damage scores and epithelial thickness were measured.
ResultsAfter topical administration of PRP and saline, the difference in the average FFT values of the groups was statistically significant at 7, 14, and 21 days (P < 0,005). During the histopathological examination, the epithelial damage score was statistically significantly lower in the PRP group (P=0.001) than in the saline group, and epithelial thickness was statistically significantly greater in the PRP group compared to the saline group (P=0.003).
ConclusionWe showed that PRP administration has a curative effect on olfactory functions in an anosmia-induced mice model. However, there is a need for further research before PRP can be considered for use in patients with anosmia in clinical practice. Level of EvidenceNA. Laryngoscope, 128:E157-E162, 2018
Açıklama
Anahtar Kelimeler
Perıpheral-Nerve Regeneratıon, Neural Stem-Cells, Olfactory Dysfunctıon, Neurotrophıc Factor, 3-Methylındole, Populatıon, Epıthelıum, Dısorders, Mouse
Kaynak
Laryngoscope
WoS Q Değeri
Scopus Q Değeri
Cilt
128
Sayı
5
Künye
Gül, M. (2018). The effectiveness of platelet-rich plasma in an anosmia-induced mice model. Cilt:128 Sayı:5, 157-162 ss.
