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Öğe The effectiveness of platelet-rich plasma in an anosmia-induced mice model(Wıley, 111 rıver st, hoboken 07030-5774, nj usa, 2018) Gül, MehmetObjectiveIn this study, we aimed to functionally and morphologically demonstrate the effectiveness of platelet-rich plasma (PRP) on anosmia in a mouse model of anosmia. Study DesignAnimal study. MethodsA total of 16 male mice were included. When selecting the mice, the food-finding test (FFT) was used to make sure that the animals could smell, and anosmia was induced by administration of intraperitoneal 3-methylindole. The mice were randomly divided into two groups of eight (groups A and B). After 1 week, topical PRP was administered to the mice in group A and topical saline was administered to the mice in group B. The FFT was again administered at 7, 14, and 21 days. The mice were sacrificed on day 21, the olfactory neuroepithelium was histopathologically examined, and the epithelial damage scores and epithelial thickness were measured. ResultsAfter topical administration of PRP and saline, the difference in the average FFT values of the groups was statistically significant at 7, 14, and 21 days (P < 0,005). During the histopathological examination, the epithelial damage score was statistically significantly lower in the PRP group (P=0.001) than in the saline group, and epithelial thickness was statistically significantly greater in the PRP group compared to the saline group (P=0.003). ConclusionWe showed that PRP administration has a curative effect on olfactory functions in an anosmia-induced mice model. However, there is a need for further research before PRP can be considered for use in patients with anosmia in clinical practice. Level of EvidenceNA. Laryngoscope, 128:E157-E162, 2018Öğe Severe vertigo after cochlear ımplantation: acute pneumolabyrinth(Galenos yayıncılık, erkan mor, molla guranı cad 21-1, fındıkzade, ıstanbul 34093, turkey, 2018) Karatas, Erkan; Toplu, Yuksel; Gunduz, Emrah; Demir, IsmailÖğe Middle turbinate angiofibroma: an unusual location for juvenile angiofibroma(ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL, AV INDIANOPOLOS 740, MOEMA, SAO PAULO, SP 04062-001, BRAZIL, 2018) Toplu, Yüksel; Can, Şermin; Şanlı, Mukadder; Şahin, Nurhan; Kızılay, AhmetÖğe Outcomes of cochlear implantation in children with and without inner ear malformations(Professıonal medıcal publıcatıons, panorama centre, rm 522, 5th floor, bldg 2, raja ghazanfar alı rd, po box 8766, saddar, karachı 00000, pakıstan, 2018) Celik, Mustafa; Karatas, Erkan; Kanlikama, MuzafferObjective: To evaluate the auditory functions and progress of speech development in children with and without cochlear anomalies who underwent cochlear implantation due to prelingual profound sensorineural hearing loss (SNHL). Methods: This study was conducted at Gaziantep University Faculty of Medicine Ear-Nose-Throat Department, between October 2006 and December 2007. A total of 69 children (aged 6 to 24 months) diagnosed with profound SNHL were included. Patients were divided into two groups with respect to the presence of inner ear anomalies: Group-1 consisted of 41 children without inner ear anomaly, whereas Group-2 was composed of 28 patients with inner ear anomalies. The auditory performance was assessed using Listening Progress Profile Test (LPPT) and Monosyllabic Trochee Polysyllabic Test (MTP), the subsections of Evaluation of Auditory Responses to Speech (EARS) test battery. Results: Preoperative LPPT scores were 5 (12%) in both groups. Mean LPPT values after fitting in Group-1 and Group-2 on 1st, 3rd and 6th months were 18.5 (44.1%) and 19 (45.6%); 27 (64.2%) and 28 (67.3%); 31 (75%) and 34 (83%), respectively. Postoperatively, MTP scores in Group-1 and Group-2 were 7.5 (62%) and 7.7 (64%) for 3-words set; 10.4 (58%) and 10.6 (59%) for 6-words set; 14.3 (60%) and 14 (59%) for 12-words set, respectively. The rate of stimulation for electrodes was 1345 q/u (quick/unit) in Group-1 and 1310 q/u in Group-2. No statistically significant difference was detected between groups for variables under investigation. Conclusion: Cochlear implantation is an effective treatment in children with prelingual profound SNHL. Auditory performance and advancement of speech are similar for children with and without inner ear anomalies.Öğe Management of cerebrospinal fluid gusher in pediatric cochlear implantation(Royal belgıan soc ear, nose, throat, head & neck surgery, po box 1248, leuven, 00000, belgıum, 2018) Karatas, EManagement of cerebrospinal fluid gusher in pediatric cochlear implantation. Objectives: This study's aim is to evaluate the management of Cerebrospinal Fluid (CSF) gusher after cochlear implantation in children postoperatively. Methodology: 120 children (age ranges 13 to 72 months) who underwent cochlear implantation and eight of them had CSF gusher intraoperatively. Successful cochlear implantations and intraoperative management performed by complete packing of the electrode around in cochleostomy with muscle for Case I to III. CSF gusher was observed in these cases postoperatively. Second and third look revision surgeries were performed. Also, fat tissue was used for the sealing of leakage in Case IV to VIII. Results: Severe CSF gusher occurred in 6 children with the common cavity, moderate in one child with Incomplete Partition (IP) type 1 and mild in one child with normal cochlea. Sealing the cochleostomy with muscle performed in the first 3 children intraoperatively and they also had CSF gusher postoperatively. Revision surgeries were performed for 3 children. Sealing the cochleostomy with fat tissue was successful in Case I and II but not in Case III. Subtotal petrosectomy and obliteration of cavity with fat tissue had been performed for Case III. CSF leakage has not been seen in the other 5 children with fat tissue packing for the postoperative long term. Conclusions: CSF gusher may occur in pediatric cochlear implantation with inner ear malformations postoperatively. Packing around the electrode in cochleostomy with muscle may not be enough. Fat tissue packing is more effective than muscle for the postoperative long term.Öğe Acoustic tamm states of three-dimensional solid-fluid phononic crystals(Acoustıcal soc amer amer ınst physıcs, ste 1 no 1, 2 huntıngton quadrangle, melvılle, ny 11747-4502 usa, 2018) Korozlu, Nurettin; Kaya, Olgun Adem; Cicek, Ahmet; Ulug, BulentIn this work, the existence and propagation of acoustic Tamm states at the interface of air and a face-centered cubic solid-fluid phononic crystal composed of spherical air voids interconnected by cylindrical air channels are demonstrated. Supercell band structure computations via the finite element method reveal surface bands for Tamm states on (100), (110), and (111) surfaces of the phononic crystal. The states decay sharply into the phononic crystal so that only a two-row slab is sufficient to guide them over the respective surfaces without leakage, as confirmed by finite element simulations. In addition, surface wave propagation along the [10] direction of the (100) surface is experimentally demonstrated. Ability to confine the Tamm states in all three dimensions is a key aspect in designing few-layer-thick acoustic circuits. Low material filling fraction of the phononic crystal could be leveraged to realize lightweight all-acoustic systems where either bulk or surface states can be incorporated. (C) 2018 Acoustical Society of America.Öğe A rare cause of dysphagia and halitosis: zenker’s diverticulum(2018) Yaslikaya, S.; Kizilay, S.In this article, we present a rare case which was diagnosed as Zenker’s diverticulum that was treated with external approach by performing cricopharyngeal myotomy and diverticulectomy. Zenker’s diverticulum occurs by herniation of the pharynx mucosa and submucosa from the weakened area between the cricop-haryngeus and the inferior constructor muscles, because of the increased pressure created by the spasm of the upper esopha-geal sphincter. It is usually seen in 7-8th decades of life and more common among men. Patients usually present with complaints of dysphagia, odynophagia, regurgitation, halitosis, and chronic cough. Currently, treatment for Zenker’s diverticulum has been mostly defined, however it has not determined precisely. The purpose of the treatment is to create a uniform flow in the lumen by preventing the diverticulum from being a reservoir. Today, endoscopic approach is frequently preferred because of low complication rates and operation times and short hospital stay. However, some authors also advocate that external approach should be applied with greater success rates for a large diverticulum and in patients who can not undergo endoscopy. In determining the treatment, the preference of the doctor, the patient’s expectation, general conditions and possibilities should be considered. © 2018, Logos Medical Publishing. All rights reserved.Öğe A new classification for septal perforation and effects of treatment methods on quality of life(2018) Sapmaz, E.; Toplu, Y.; Somuk, BTIntroduction: Septal perforation is a condition characterized by loss of cartilage and/or bony structures along with the mucoperichondrium and mucoperiosteum lining them. The etiology includes a history of nasal surgery or trauma, nose picking, bilateral septal cauterization, overuse of nasal sprays, cocaine abuse, vasculitis, and malignancies. Objective: Comparison of quality of life in patients with septal perforation after conservative or surgical treatment, and a new approach for the determination of the diameter of the perforation from a different point of view. Methods: The diameter of septal perforation, total vertical diameter of septum, and horizontal diameter of the perforation were measured in a total of 34 patients. Nineteen of the patients underwent surgical septal perforation repair, and 15 of them received septal button application. The patients were asked to complete the Glasgow Benefit Inventory quality of life questionnaire. Results: The septal perforation successfully healed in 18 of 19 patients who underwent surgical treatment. The quality of life scores were statistically significantly higher in the surgical treatment group when compared to the button group (p < 0.05). Conclusion: The septal perforation classification we propose would be beneficial for providing realistic dimensions, treatment methods, and surgical techniques. © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-FacialÖğe Prolonged arterial spasm in an ear replantation without venous anastomosis(J Reconstr Microsurg., 1997) Kayıkçıoğlu, A.; Özlüoğlu, L.; Kızılay, AhmetSuccessful ear replantations are rare. The authors report a case in which 75 percent of the ear survived with an arterial anastomosis only. An extended period of time must be allowed for relief of arterial spasm in replants with tiny vessel diameters.Öğe Calcified Mucor fungus ball of sphenoid sinus an unusual presentation of sinoorbital mucormycosis(Ann Otol Rhinol Laryngol., 1997) Saydam, Levent; Erpek, Gökhan; Kızılay, AhmetÖğe Ancient cervical vagal neurilemmoma a case report(Am J Otolaryngol., 2000) Saydam, Levent; Kızılay, Ahmet; Kalcıoğlu, Mahmut Tayyar; Gürer, İnançSchwannoInas (neurilemmomas) are benign, encapsulated tumors of neural sheath origin. Although more commonly encountered in the extremities, approximately 25 % of the cases are originated from the neural structures of head and neck region. 1 Ancient schwannoma is a rare variant of schwannomas. It was first described by Ackerman and Taylor 2 in 1951. In this series of 48 neurogenous tumors of the thorax, the investigators reported 10 cases that differed from the rest of the cases with their distinctive histopathologic characteristics such as large areas of hyalinized matrix, increased hypercellularity with nuclear pleomorphism, and hyperchromatism. Ackerman and Taylor stated that these features occurred in the schwannomas of long duration, and thus they designated the entity as ancient schwannoma. First ancient schwannoma of head and neck region was reported by Eversole and Howell 3 in 1971. Most of the reported head and neck cases were found to be located at pharyngeal walls or oral cavity, with 2 exceptions of infratemporal fossa and parotid regions. To the best of our knowledge, the following is the first reported case of an ancient cervical vagal schwannoma.Öğe Audio vestibular evaluation in patients with behçets syndrome(J Laryngol Otol, 2001) Evereklioğlu, Cem; Çokkeser, Yaşar; Doğanay, Selim; Er, Hamdi; Kızılay, AhmetA prospective controlled clinical study was carried out at the Department of Ophthalmology and ENT, Ino¨ nu¨ University Medical Faculty, Turgut Ozal Medical Center, Research Hospital, to evaluate the audiovestibular involvement in patients with Behc¸et’s syndrome compared with controls. Twenty- ve consecutive patients with Behc¸et’s syndrome (mean age 6 SD, 34.96 6 8.50) and 20 ageand sex-matched healthy volunteers (hospital staff) as control subjects (mean age 6 SD, 34.45 6 9.16) were included in this study. Behc¸et’s patients were divided into two groups according to the number of criteria, complete (all four major criteria) and incomplete (three major criteria without ocular involvement). The groups were compared with each other or controls regarding inner ear involvement. Audiometric pure-tone thresholds at 125 to 8000 Hz were obtained in all subjects in both groups, and pure tone average (PTA) hearing thresholds were calculated for the middle, high and low frequencies. In addition, short increment sensitivity index (SISI), tone decay and BERA examinations were performed in all Behc¸et’s patients. Sensorineural hearing loss (SNHL) was present in six of 25 patients with Behc¸et’s syndrome. Two Behc¸et’s patients had unilateral total SNHL, two had bilateral moderate level SNHL, one had bilateral low-frequency SNHL and one bilateral high frequency SNHL. In two, BERA, and in ve SISI, examination disclosed inner ear involvement. In control subjects, the past medical history was normal and there was no consistent audio-vestibular complaint. Their PTA thresholds were all in the normal range. Otoscopic examination ndings were normal, with intact, mobile tympanic membranes in both groups. The present study showed that audio-vestibular involvement is not infrequent in Behc¸et’s syndrome compared with age- and sex-matched healthy controls, and it is under-estimated. All Behc¸et’s patients should regularly be followed by an otolaryngologists and be given information about the possibility of inner ear involvement. According to our results, hearing loss occurs more often in older patients and also in the complete form of Behc¸et’s syndrome.Öğe Dural bone defects and encephalocele associated with chronic otitis media or its surgery(Kulak Burun Boğaz İhtisas Dergisi, 2002) Kızılay, Ahmet; Aladağ, I.; Çokkeser, Yaşar; Özturan, OrhanWe investigated the incidence of dural bone defects and encephalocele following radical mastoidectomy or open cavity tympanoplasty. We retrospectively evaluated 190 operations of 182 patients (97 males, 85 females; mean age 30.6 years; range 9 to 70 years) who underwent radical mastoidectomy (n=89) or open cavity tympanoplasty (n=101). Follow-up examinations included otomicroscopy. Patients with documented dural bone defects on examination or operation records were further evaluated by axial and coronal computed tomography scans of the temporal bone. Those with suspected encephalocele were studied by magnetic resonance imaging. Dural bone defects were detected in 17 patients perioperatively. Of these, 14 defects were associated with chronic otitis media. Three iatrogenic bone defects were induced during obliteration of lateral sinus thrombosis. The mastoid tegmen was the most common site of defects (41%) and the most common etiologic factor was cholesteatoma (84%). Encephalocele was detected in one patient in whom radical mastoidectomy with lateral sinus obliteration was performed due to lateral sinus thrombophlebitis. Encephalomalasia was found nearby the defect area in two patients. Dural bone defects associated with chronic otitis media are not rare, the most common cause being cholesteatoma. Repair of dural lacerations requires watertight closure to prevent the occurrence of encephalocele.Öğe Early oral feeding following total laryngectomy(Am J Otolaryngol, 2002) Saydam, Levent; Kalcıoğlu, Mahmut Tayyar; Kızılay, AhmetIntroduction: Pharyngocutaneous fistula is one of the most common nonfatal laryngectomy complications (7.6% to 65% of all total patients). Preoperative radiotherapy, advanced tumor stage, poor preoperative medical status, and concomitant pharyngectomy are usually accepted causative factors in fistula formation. Delay of oral feeding is a common practice used by head and neck surgeons to prevent the development of pharyngocutaneous fistula. In this article we analyze our experience with special emphasis given to the early start of postoperative feeding. Patients and Methods: The postoperative records of 48 patients who had undergone total laryngectomy or total laryngopharyngectomy were reviewed. All patients were orally fed with water and clear liquids on the first postoperative day. The patients were closely observed at every feeding attempt, and if any sign of fistula was noted, a nasogastric tube was inserted. Preoperative radiotherapy, stage of disease, tumor differentiation, and pharyngectomy with total laryngectomy were statistically analyzed as potential risk factors contributing to fistula formation. The Fisher exact test was used to analyze the data. Results: The overall pharyngocutaneous fistula rate was 12.5% in our series. The only statistically significant factor that increased the rate of fistula formation was resection of pharyngeal mucosa as an extension of total laryngectomy. Other parameters failed to show any statistical significance in development of this complication. Conclusion: Evaluation of fistula incidence in our series indicates that initiating oral feeding on the first postoperative day does not contribute to fistula formation. Additionally, the relatively shortened hospital stay and elimination of the psychologic and traumatic side effects of tube feeding are benefits of this approach that should be studied in further prospective quality-of-life studies.Öğe Synovial sarcoma of the pharynx a case report(Ear Nose Throat J., 2002) Saydam, Levent; Kızılay, Ahmet; Kalcıoğlu, Mahmut Tayyar; Mızrak, Bülent; Bulut, FatihÖğe Bending of the upper lateral cartilages for nasal valve collapse(Arch Facial Plast Surg, 2002) Özturan, Orhan; Miman, Murat Cem; Kızılay, AhmetAs a consequence of removal of the nasal hump, the upper lateral cartilages are separated from the septal cartilage in reductive rhinoplasty. A decrease in the nasal airway cross-sectional area and collapse of the internal nasal valve (INV) are inevitable unless additional surgical measures are taken. To determine the efficacy of the horizontal mattress bending suture in treating patients with nasal valve collapse. Each upper lateral cartilage was separately bent to a certain degree with a horizontal mattress suture following nasal dorsum reduction in the external septorhinoplasty as a preventive or corrective measure for the INV stenosis. The efficacy of this suture was assessed in 28 patients who presented with tension nose by comparing the INV angles preoperatively and 12 months postoperatively, as determined photographically by means of a rigid nasal endoscope. The mean +/- SD preoperative INV angle was calculated as 9.1 degrees +/- 4.2 degrees (range, 0 degrees -18.3 degrees ). The mean postoperative INV angle was increased to 25.3 degrees +/- 3.8 degrees (range, 18.4 degrees -34.5 degrees ) (P<.001). This method reconstitutes the normal anatomy of the INV, reestablishes stiffness or resistance of the nasal side walls so that they do not bend inwardly with inspiration, improves the airflow at this area, and avoids postoperative nasal valve stenosis in functional-cosmetic rhinoplasty cases that require considerable nasal hump reduction.Öğe The evaluation of thyroid nodules is routine use of frozen section examination necessary followingpreoperative fine needle aspiration biopsy(Kulak Burun Bogaz Ihtisas Dergisi, 2003) Saydam, Levent; Kalcıoğlu, Mahmut Tayyar; Kızılay, Ahmet; Bozkurt, Mete KaanAmeliyat öncesi ince i¤ne aspirasyon biyopsisi (‹‹AB) sonuçlar›n› tek parametre olarak kullanarak tiroidektominin geniflli¤ine karar verilip verilemeyece¤i ve frozen section incelemesinin her olguda rutin olarak gerekip gerekmedi¤i araflt›r›ld›. Hastalar ve Yöntemler: Çal›flmaya nodüler tiroit tan›s›yla tiroidektomi ameliyat› yap›lan ve ameliyat öncesinde ince i¤ne aspirasyonu (n=46) ve/veya ameliyat s›ras›nda frozen section (n=40) sonuçlar›na ula- fl›labilen 67 hasta (40 kad›n, 27 erkek; ort. yafl 44; da¤›l›m 17-78) al›nd›. ‹ki yöntemin sonuçlar›yla patolojik inceleme sonuçlar› karfl›laflt›r›ld›. Bulgular: Histopatolojik sonuçlar 25 olguda (%37.3) malign, 42 olguda (%62.7) benign bulundu. ‹nce i¤- ne aspirasyon biyopsisinin duyarl›l›¤› %50, özgüllü- ¤ü %95, tan›sal do¤ruluk oran› %77; frozen section incelemesinin duyarl›l›¤› %100, özgüllü¤ü %87, tan›- sal do¤rulu¤u %91 bulundu. Sonuç: Bulgular›m›z, ‹‹AB’nin düflük duyarl›l›k ve tan›- sal do¤ruluk de¤erleri nedeniyle, klinik malignensi parametrelerinin dikkatle de¤erlendirilmesi ile birlikte rutin frozen section incelemesinin gerekli oldu¤unu göstermektedir.Öğe The effect of endoscopic sinus surgery on quality of life(Kulak Burun Bogaz Ihtisas Dergisi, 2003) Akarçay, Mustafa; Kızılay, Ahmet; Miman, Murat Cem; Çokkeser, Yaşar; Özturan, OrhanWe assessed the effects of endoscopic sinus surgery on quality of life of patients with nasal polyposis or chronic sinusitis. PATIENTS AND METHODS: Thirty patients (5 females, 25 males; mean age 36 years; range 17 to 58 years) who underwent endoscopic sinus surgery were prospectively evaluated. The diagnoses were nasal polyposis in 15 patients and chronic sinusitis in 15 patients. Primary and revision operations were performed in 23 patients and seven patients, respectively. The quality of life was evaluated before and six months after surgery with the use of the Chronic Sinusitis Survey (CSS), and Medical Outcomes Study Short Form-12 (SF-12). Prior to administration, the two questionnaires were translated and adapted to Turkish. Computed tomography (CT) findings were scored before and six months after surgery according to the Lund-Mackay system. The results of the surveys were compared with CT scores. RESULTS: The postoperative SF-12 and CSS scores of all the patients improved significantly. Computed tomography scores were not found in correlation with improvements in the SF-12 and CSS scores. CONCLUSION: Endoscopic sinus surgery results in significant improvement in the quality of life of patients with nasal polyposis and chronic sinusitis, which may not be reflected by CT scores.Öğe Successful use of botulinum toxin injection in the treatment of salivary fistula following parotidectomy(Kulak Burun Bogaz Ihtisas Dergisi, 2003) Kızılay, Ahmet; Aladağ, I.; Özturan, OrhanA twenty-year-old woman underwent right superficial parotidectomy for pleomorphic adenoma. On the 10th postoperative day she presented with a salivary fistula, for which repeated aspirations with pressure dressings were applied for a month. Despite decreases in the salivary fluid volume, reaccumulation persisted. Following aspiration of the salivary fluid, 40 units of botulinum toxin was injected into the pouch. On the second day of injection, the discharge ceased and the pouch disappeared. No side effects were observed and the patient remained symptom-free during four-month follow-up.Öğe Effects of partial neuromuscular blockade on facial nerve monitorization in otologic surgery(Acta Otolaryngol, 2003) Kızılay, Ahmet; Aladağ, İbrahim; Çokkeser, Yaşar; Miman, Murat Cem; Özturan, Orhan; Gülhaş, NurçinNeuromuscular blockade (NMB) is administered as part of a general anesthetic in order to keep the patient immobilized during surgery and has been known to hinder intraoperative neuromonitorization. The aim of this study was to determine the effects of different levels of NMB on electrical stimulation thresholds of the facial nerve during otologic surgery. Material and Methods—Intraoperative facial nerve monitorization was performed in 29 patients with advanced middle ear disease. Electromyographic (EMG) responses were recorded by insertion of needle electrodes into the orbicularis oris and orbicularis oculi muscles. Minimal facial nerve stimulations causing EMG responses in the facial musculature were measured during full recovery from the effects of muscular relaxants and with 25%, 50%, 75% and 100% levels of NMB. These defined NMB levels were maintained by the administration of a drip infusion of atracurium and were assessed objectively by recording the hypothenar muscle action. Results—All of the patients had detectable EMG responses of the facial musculature at the 50% and 75% levels of NMB in response to the electrical stimulation of the facial nerve. The corresponding mean stimulation thresholds were 0.10 0.08 and 0.11 0.09 mA, respectively. No responses were measured in 31% of the patients when the level of peripheral NMB was 100%. Conclusion—This study suggests that a regulated 50% level of peripheral NMB provides reliable intraoperative EMG monitoring of the facial musculature in response to electrical stimulation and adequate anesthesia, with full immobilization of the patient.
