Increased Systemic Immune-Inflammation Index as a Novel Indicator of Alzheimer's Disease Severity

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dc.contributor.authorAlgul, Fatma E.
dc.contributor.authorKaplan, Yuksel
dc.date.accessioned2026-04-04T13:33:14Z
dc.date.available2026-04-04T13:33:14Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractIntroduction: Inflammatory processes and neurodegeneration are common features of Alzheimer's disease (AD). The systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are easily accessible, cost-effective prognostic indicators of inflammation status. We assessed the diagnostic value of SII and compared the efficacies of NLR, PLR, and SII in predicting AD severity. Materials and Methods: Between January 2021 and December 2022, this prospective, cross-sectional clinical study included 175 patients with AD and 61 controls. SII, NLR, and PLR were calculated. Results Age, white blood cell and lymphocyte counts, and NLR and PLR values were significantly different between the patient and control groups (P <.05). Age, hemoglobin, neutrophil, NLR, and SII values were significantly different among dementia severity subgroups (P <.05). Compared with PLR and SII, NLR was more strongly correlated with dementia severity. In the analysis of adjusted data by gender, it was found that hemoglobin level is significantly negatively associated with dementia severity in males, while in females, age and PLR are significantly positively associated with dementia severity, and lymphocyte count and SII are negatively associated. Conclusion: SII, a novel inflammatory marker, was associated with dementia severity in patients with AD. Compared with PLR and SII, NLR was more strongly correlated with dementia severity. In future studies with larger populations, SII and NLR values can be used to determine dementia severity and establish follow-up plans for patients with high dementia risk.
dc.identifier.doi10.1177/08919887241280880
dc.identifier.endpage222
dc.identifier.issn0891-9887
dc.identifier.issn1552-5708
dc.identifier.issue3
dc.identifier.orcid0000-0003-0318-7571
dc.identifier.pmid39271460
dc.identifier.scopus2-s2.0-85204118532
dc.identifier.scopusqualityQ1
dc.identifier.startpage214
dc.identifier.urihttps://doi.org/10.1177/08919887241280880
dc.identifier.urihttps://hdl.handle.net/11616/109018
dc.identifier.volume38
dc.identifier.wosWOS:001313585200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Geriatric Psychiatry and Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAlzheimer's disease
dc.subjectsystemic immune-inflammation index
dc.subjectneutrophil-to-lymphocyte ratio
dc.subjectplatelet-to-lymphocyte ratio
dc.titleIncreased Systemic Immune-Inflammation Index as a Novel Indicator of Alzheimer's Disease Severity
dc.typeArticle

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